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- Publisher Website: 10.1016/j.jpba.2006.09.009
- Scopus: eid_2-s2.0-33846564893
- PMID: 17029672
- WOS: WOS:000244623000017
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Article: Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization
Title | Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization |
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Authors | |
Keywords | Adventitious roots Dencichine Ethyl chloroformate (ECF) Gas chromatography-mass spectrometry Panax notoginseng |
Issue Date | 2007 |
Citation | Journal of Pharmaceutical and Biomedical Analysis, 2007, v. 43, n. 3, p. 920-925 How to Cite? |
Abstract | Dencichine (β-N-oxalyl-l-α,β-diaminopropionic acid) is a haemostatic agent present in well-known traditional Chinese medicinal herbs such as Panax notoginseng, as well as other Panax species. It is also a reported neurotoxic agent found in Lathyrus sativus (grass pea seed) and cycad seeds. A method was developed for quantitative determination of the non-protein amino acid, dencichine, in plant samples of P. notoginseng and the adventitious roots directly from the explants of P. notoginseng after derivatization with ethyl chloroformate (ECF) by gas chromatography-mass spectrometry (GC-MS). l-2-chlorophenylalanine was used as an internal standard. Calibration curves were linear (r2 = 0.9988, n = 6) in the range of 10-800 μg/ml for dencichine. Limit of detection and quantification for dencichine were 0.5 μg/ml and 2 μg/ml, respectively. This rapid and specific method may be applied to the quantification of dencichine in complex medicinal plants and their products. © 2006 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/342304 |
ISSN | 2021 Impact Factor: 3.571 2020 SCImago Journal Rankings: 0.777 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xie, Guo Xiang | - |
dc.contributor.author | Qiu, Yun Ping | - |
dc.contributor.author | Qiu, Ming Feng | - |
dc.contributor.author | Gao, Xian Fu | - |
dc.contributor.author | Liu, Yu Min | - |
dc.contributor.author | Jia, Wei | - |
dc.date.accessioned | 2024-04-17T07:02:50Z | - |
dc.date.available | 2024-04-17T07:02:50Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Journal of Pharmaceutical and Biomedical Analysis, 2007, v. 43, n. 3, p. 920-925 | - |
dc.identifier.issn | 0731-7085 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342304 | - |
dc.description.abstract | Dencichine (β-N-oxalyl-l-α,β-diaminopropionic acid) is a haemostatic agent present in well-known traditional Chinese medicinal herbs such as Panax notoginseng, as well as other Panax species. It is also a reported neurotoxic agent found in Lathyrus sativus (grass pea seed) and cycad seeds. A method was developed for quantitative determination of the non-protein amino acid, dencichine, in plant samples of P. notoginseng and the adventitious roots directly from the explants of P. notoginseng after derivatization with ethyl chloroformate (ECF) by gas chromatography-mass spectrometry (GC-MS). l-2-chlorophenylalanine was used as an internal standard. Calibration curves were linear (r2 = 0.9988, n = 6) in the range of 10-800 μg/ml for dencichine. Limit of detection and quantification for dencichine were 0.5 μg/ml and 2 μg/ml, respectively. This rapid and specific method may be applied to the quantification of dencichine in complex medicinal plants and their products. © 2006 Elsevier B.V. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Pharmaceutical and Biomedical Analysis | - |
dc.subject | Adventitious roots | - |
dc.subject | Dencichine | - |
dc.subject | Ethyl chloroformate (ECF) | - |
dc.subject | Gas chromatography-mass spectrometry | - |
dc.subject | Panax notoginseng | - |
dc.title | Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jpba.2006.09.009 | - |
dc.identifier.pmid | 17029672 | - |
dc.identifier.scopus | eid_2-s2.0-33846564893 | - |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 920 | - |
dc.identifier.epage | 925 | - |
dc.identifier.isi | WOS:000244623000017 | - |