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Article: Using Chinese natural products for diabetes mellitus drug discovery and development
Title | Using Chinese natural products for diabetes mellitus drug discovery and development |
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Authors | |
Keywords | Combination herbal formulae Diabetes mellitus Multi-component therapeutics Traditional Chinese medicine |
Issue Date | 2007 |
Citation | Expert Opinion on Drug Discovery, 2007, v. 2, n. 7, p. 977-986 How to Cite? |
Abstract | This paper provides a review of natural Chinese drug products, including phytochemic compounds, medicinal herbs and multi-component herbal formulae, that have been reported to possess hypoglycemic activity with mechanisms for antidiabetic action. Along with a great number of combination formulae, - 187 different Chinese medicinal herbs are clinically applied to treat diabetes mellitus and its complications in China, most of which have achieved reasonably good clinical outcomes. These valuable data and practical experience provide a promising opportunity for the discovery and development of drug candidates with good therapeutic efficacy and low toxicity. The concept of treating complex, multifactorial metabolic diseases, such as diabetes, using multi-component therapeutics, including single-herb formulae and combination herbal formulae, shall be regarded as a concerted pharmacologic intervention of multiple compounds interacting with multiple targets and possessing interdependent activities that are required for a synergistic or optimal effect. The conventional approach for the discovery and development of antidiabetic drug products from natural products involving a high-throughput, bioactivity guided drug screening of single compounds obtained from thousands of herbs has proven to be a costly and non-productive effort. Hence, an alternative way of developing new drug candidates, as suggested in this review, is to reduce and simplify a well-established combination herbal formula, along with the pharmacologic evaluation of a small group of phytochemic compounds, which are therapeutically effective as the original formula and have known chemical structures, compositions and mechanisms of action that are similar to chemical drugs. © 2007 Informa UK Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/342313 |
ISSN | 2023 Impact Factor: 6.0 2023 SCImago Journal Rankings: 1.077 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tao, Xiumei | - |
dc.contributor.author | Wang, Xiaoyan | - |
dc.contributor.author | Jia, Wei | - |
dc.date.accessioned | 2024-04-17T07:02:54Z | - |
dc.date.available | 2024-04-17T07:02:54Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Expert Opinion on Drug Discovery, 2007, v. 2, n. 7, p. 977-986 | - |
dc.identifier.issn | 1746-0441 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342313 | - |
dc.description.abstract | This paper provides a review of natural Chinese drug products, including phytochemic compounds, medicinal herbs and multi-component herbal formulae, that have been reported to possess hypoglycemic activity with mechanisms for antidiabetic action. Along with a great number of combination formulae, - 187 different Chinese medicinal herbs are clinically applied to treat diabetes mellitus and its complications in China, most of which have achieved reasonably good clinical outcomes. These valuable data and practical experience provide a promising opportunity for the discovery and development of drug candidates with good therapeutic efficacy and low toxicity. The concept of treating complex, multifactorial metabolic diseases, such as diabetes, using multi-component therapeutics, including single-herb formulae and combination herbal formulae, shall be regarded as a concerted pharmacologic intervention of multiple compounds interacting with multiple targets and possessing interdependent activities that are required for a synergistic or optimal effect. The conventional approach for the discovery and development of antidiabetic drug products from natural products involving a high-throughput, bioactivity guided drug screening of single compounds obtained from thousands of herbs has proven to be a costly and non-productive effort. Hence, an alternative way of developing new drug candidates, as suggested in this review, is to reduce and simplify a well-established combination herbal formula, along with the pharmacologic evaluation of a small group of phytochemic compounds, which are therapeutically effective as the original formula and have known chemical structures, compositions and mechanisms of action that are similar to chemical drugs. © 2007 Informa UK Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Expert Opinion on Drug Discovery | - |
dc.subject | Combination herbal formulae | - |
dc.subject | Diabetes mellitus | - |
dc.subject | Multi-component therapeutics | - |
dc.subject | Traditional Chinese medicine | - |
dc.title | Using Chinese natural products for diabetes mellitus drug discovery and development | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1517/17460441.2.7.977 | - |
dc.identifier.scopus | eid_2-s2.0-34547404670 | - |
dc.identifier.volume | 2 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 977 | - |
dc.identifier.epage | 986 | - |
dc.identifier.isi | WOS:000207617000007 | - |