File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Metabolic regulatory network alterations in response to acute cold stress and ginsenoside intervention

TitleMetabolic regulatory network alterations in response to acute cold stress and ginsenoside intervention
Authors
KeywordsAcute cold stress
Gas chromatography/mass spectrometry
Ginsenosides
Metabolic profiling
Metabonomics
Multivariate statistical analysis
Issue Date2007
Citation
Journal of Proteome Research, 2007, v. 6, n. 9, p. 3449-3455 How to Cite?
AbstractAcute stress may trigger systemic biochemical and physiological changes in living organisms, leading to a rapid loss of homeostasis, which can be gradually reinstated by self-regulatory mechanisms and/or drug intervention strategy. However, such a sophisticated metabolic regulatory process has so far been poorly understood, especially from a holistic view. Urinary metabolite profiling of Sprague-Dawley rats exposed to cold temperature (-10°C) for 2 h using GC/MS in conjunction with modern multivariate statistical techniques revealed drastic biochemical changes as evidenced by fluctuations of urinary metabolites and demonstrated the protective effect of total ginsenosides (TGs) in ginseng extracts on stressed rats. The metabonomics approach enables us to visualize significant alterations in metabolite expression patterns as a result of stress-induced metabolic responses and post-stress compensation, and drug intervention. Several major metabolic pathways including catecholamines, glucocorticoids, the tricarboxylic acid (TCA) cycle, tryptophan (nicotinate), and gut microbiota metabolites were identified to be involved in metabolic regulation and compensation required to restore homeostasis. © 2007 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/342317
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Xiaoyan-
dc.contributor.authorSu, Mingming-
dc.contributor.authorQiu, Yunping-
dc.contributor.authorNi, Yan-
dc.contributor.authorZhao, Tie-
dc.contributor.authorZhou, Mingmei-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorYang, Shengli-
dc.contributor.authorZhao, Liping-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:02:56Z-
dc.date.available2024-04-17T07:02:56Z-
dc.date.issued2007-
dc.identifier.citationJournal of Proteome Research, 2007, v. 6, n. 9, p. 3449-3455-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342317-
dc.description.abstractAcute stress may trigger systemic biochemical and physiological changes in living organisms, leading to a rapid loss of homeostasis, which can be gradually reinstated by self-regulatory mechanisms and/or drug intervention strategy. However, such a sophisticated metabolic regulatory process has so far been poorly understood, especially from a holistic view. Urinary metabolite profiling of Sprague-Dawley rats exposed to cold temperature (-10°C) for 2 h using GC/MS in conjunction with modern multivariate statistical techniques revealed drastic biochemical changes as evidenced by fluctuations of urinary metabolites and demonstrated the protective effect of total ginsenosides (TGs) in ginseng extracts on stressed rats. The metabonomics approach enables us to visualize significant alterations in metabolite expression patterns as a result of stress-induced metabolic responses and post-stress compensation, and drug intervention. Several major metabolic pathways including catecholamines, glucocorticoids, the tricarboxylic acid (TCA) cycle, tryptophan (nicotinate), and gut microbiota metabolites were identified to be involved in metabolic regulation and compensation required to restore homeostasis. © 2007 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectAcute cold stress-
dc.subjectGas chromatography/mass spectrometry-
dc.subjectGinsenosides-
dc.subjectMetabolic profiling-
dc.subjectMetabonomics-
dc.subjectMultivariate statistical analysis-
dc.titleMetabolic regulatory network alterations in response to acute cold stress and ginsenoside intervention-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr070051w-
dc.identifier.pmid17658780-
dc.identifier.scopuseid_2-s2.0-34948835721-
dc.identifier.volume6-
dc.identifier.issue9-
dc.identifier.spage3449-
dc.identifier.epage3455-
dc.identifier.isiWOS:000249371000011-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats