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Article: Effect of Jinfu Kang to experimental precancerous colon lesions and urinary metabolites in rat

TitleEffect of Jinfu Kang to experimental precancerous colon lesions and urinary metabolites in rat
Authors
Keywords1, 2-dimethylhydrazine (DMH)
Jinfu Kang
Pattern recognize
Precancerous colon; metabonomics
Issue Date2008
Citation
Zhongguo Zhongyao Zazhi, 2008, v. 33, n. 22, p. 2653-2657 How to Cite?
AbstractObjective: To profile urinary metabolite variations from 1, 2-dimethylhydrazine (DMH)-induced precancerous colon rats, Jinfu Kang treated rats and healthy controls. Method: We used ethyl chloroformate derivatization and gas chromatographymass spectrometry (GC-MS) based metabonomic method to analyze rat urines. Result: The time-dependent variations of metabolite profile showed a progressive deviation of the metabolism in die model group from the initial pattern over time and a systemic recovery of the metabolism in the treatment group, which is consistent with the histological results. The in-depth analysis indicated that the disorder of tricarboxylic acid cycle (TCA), tryptophan metabolism, polyamine metabolism and gut flora structure were associated with DMH intervention. Conclusion: Metabolic study revealed that Jinfu Kang can effectively reverse metabolic departures in DMH-induced precancerous colon rat, which is consistent with pathological results.
Persistent Identifierhttp://hdl.handle.net/10722/342339
ISSN
2023 SCImago Journal Rankings: 0.206

 

DC FieldValueLanguage
dc.contributor.authorQiu, Yin Ping-
dc.contributor.authorSu, Ming Ming-
dc.contributor.authorWu, Da Zheng-
dc.contributor.authorZhao, Ai Hua-
dc.contributor.authorLiu, Yu Min-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:05Z-
dc.date.available2024-04-17T07:03:05Z-
dc.date.issued2008-
dc.identifier.citationZhongguo Zhongyao Zazhi, 2008, v. 33, n. 22, p. 2653-2657-
dc.identifier.issn1001-5302-
dc.identifier.urihttp://hdl.handle.net/10722/342339-
dc.description.abstractObjective: To profile urinary metabolite variations from 1, 2-dimethylhydrazine (DMH)-induced precancerous colon rats, Jinfu Kang treated rats and healthy controls. Method: We used ethyl chloroformate derivatization and gas chromatographymass spectrometry (GC-MS) based metabonomic method to analyze rat urines. Result: The time-dependent variations of metabolite profile showed a progressive deviation of the metabolism in die model group from the initial pattern over time and a systemic recovery of the metabolism in the treatment group, which is consistent with the histological results. The in-depth analysis indicated that the disorder of tricarboxylic acid cycle (TCA), tryptophan metabolism, polyamine metabolism and gut flora structure were associated with DMH intervention. Conclusion: Metabolic study revealed that Jinfu Kang can effectively reverse metabolic departures in DMH-induced precancerous colon rat, which is consistent with pathological results.-
dc.languageeng-
dc.relation.ispartofZhongguo Zhongyao Zazhi-
dc.subject1, 2-dimethylhydrazine (DMH)-
dc.subjectJinfu Kang-
dc.subjectPattern recognize-
dc.subjectPrecancerous colon; metabonomics-
dc.titleEffect of Jinfu Kang to experimental precancerous colon lesions and urinary metabolites in rat-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19216165-
dc.identifier.scopuseid_2-s2.0-57249097792-
dc.identifier.volume33-
dc.identifier.issue22-
dc.identifier.spage2653-
dc.identifier.epage2657-

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