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Article: Transcriptomic and metabonomic profiling of obesity-prone and obesity-resistant rats under high fat diet

TitleTranscriptomic and metabonomic profiling of obesity-prone and obesity-resistant rats under high fat diet
Authors
KeywordsFree fatty acid
High fat diet
Insulin resistance
Metabolic disorders
Microarray
Issue Date2008
Citation
Journal of Proteome Research, 2008, v. 7, n. 11, p. 4775-4783 How to Cite?
AbstractRodents respond to chronic high fat diet in at least two ways: some of them may readily gain body weight and become obese (termed obesity-prone, OP), and others may not (termed obesity-resistant, OR). Transcriptomic and metabonomic profiling of OP and OR rats has been conducted, showing two sets of significantly different phenotypic profiles in response to 16 weeks of high fat diet. We observed significant differences in transcriptional expression of nearly 80 genes, some of which are known to be involved in lipid metabolism, transport, and ketone body production. The different metabolic profiles in liver tissue extracts, serum, and urine between the two phenotypes can be ascribed to the corresponding pathways identified with multivariate statistical analysis, including fatty acid metabolism, Krebs cycle, and amino acid metabolism. The integration of results from transcriptomic and metabonomic studies revealed that the altered metabolic pathways in OP rats may involve the increased activity of sympathetic nervous system and Krebs cycle, an increased production of ketone bodies, and an adaptive regulatory process to store excessive lipids in liver through reverse cholesterol transport process. These biochemical variations at transcriptional and metabolic levels as a result of dietary intervention highlight the significance of combined "omics" strategy in the mechanistic study of obesity and metabolic disorders. © 2008 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/342341
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Houkai-
dc.contributor.authorXie, Zuoquan-
dc.contributor.authorLin, Jingchao-
dc.contributor.authorSong, Huaiguang-
dc.contributor.authorWang, Qi-
dc.contributor.authorWang, Ke-
dc.contributor.authorSu, Mingming-
dc.contributor.authorQiu, Yunping-
dc.contributor.authorZhao, Tie-
dc.contributor.authorSong, Kai-
dc.contributor.authorWang, Xiaoyan-
dc.contributor.authorZhou, Mingmei-
dc.contributor.authorLiu, Ping-
dc.contributor.authorZhao, Guoping-
dc.contributor.authorZhang, Qinghua-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:06Z-
dc.date.available2024-04-17T07:03:06Z-
dc.date.issued2008-
dc.identifier.citationJournal of Proteome Research, 2008, v. 7, n. 11, p. 4775-4783-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342341-
dc.description.abstractRodents respond to chronic high fat diet in at least two ways: some of them may readily gain body weight and become obese (termed obesity-prone, OP), and others may not (termed obesity-resistant, OR). Transcriptomic and metabonomic profiling of OP and OR rats has been conducted, showing two sets of significantly different phenotypic profiles in response to 16 weeks of high fat diet. We observed significant differences in transcriptional expression of nearly 80 genes, some of which are known to be involved in lipid metabolism, transport, and ketone body production. The different metabolic profiles in liver tissue extracts, serum, and urine between the two phenotypes can be ascribed to the corresponding pathways identified with multivariate statistical analysis, including fatty acid metabolism, Krebs cycle, and amino acid metabolism. The integration of results from transcriptomic and metabonomic studies revealed that the altered metabolic pathways in OP rats may involve the increased activity of sympathetic nervous system and Krebs cycle, an increased production of ketone bodies, and an adaptive regulatory process to store excessive lipids in liver through reverse cholesterol transport process. These biochemical variations at transcriptional and metabolic levels as a result of dietary intervention highlight the significance of combined "omics" strategy in the mechanistic study of obesity and metabolic disorders. © 2008 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectFree fatty acid-
dc.subjectHigh fat diet-
dc.subjectInsulin resistance-
dc.subjectMetabolic disorders-
dc.subjectMicroarray-
dc.titleTranscriptomic and metabonomic profiling of obesity-prone and obesity-resistant rats under high fat diet-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr800352k-
dc.identifier.pmid18828625-
dc.identifier.scopuseid_2-s2.0-58149382045-
dc.identifier.volume7-
dc.identifier.issue11-
dc.identifier.spage4775-
dc.identifier.epage4783-
dc.identifier.isiWOS:000260792000017-

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