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Article: Study on effects of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose reductase in vitro

TitleStudy on effects of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose reductase in vitro
Authors
Yang, Hong ZhouZhou, Ming MeiZhao, Ai HuaXing, Shu NingFan, Zi QuanJia, Wei
Issue Date2009
Citation
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2009, v. 32, n. 8, p. 1259-1261 How to Cite?
AbstractOBJECTIVE: To observe the activities of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose reductase (AR) by a screening model of aldose reductase inhibitor (ARI) in vitro. METHODS: The inhibition of AR by baicalin, berberine and Astragalus polysaccharides and positive drug (Epalrestat) in different concentrations were evaluated, and their combinative effects were studied according to orthogonal t design. RESULTS: Baicalin and berberine had remarkable inhibitory effects on AR, the inhibitory rates were (88.4 +/- 7.4)% and (69.0 +/- 9.4)% at the concentration of 300 microg/mL. However, the combinative effect of the inhibition on AR by the two compounds was antagonistic action. Astragalus polysaccharides had no activity of inhibition on AR. CONCLUSION: Baicalin and berberine are the potential AR inhibitors as they can inhibit the activity of AR in vitro.
Persistent Identifierhttp://hdl.handle.net/10722/342381
ISSN
1001-4454
2020 SCImago Journal Rankings: 0.125

 

DC FieldValueLanguage
dc.contributor.authorYang, Hong Zhou-
dc.contributor.authorZhou, Ming Mei-
dc.contributor.authorZhao, Ai Hua-
dc.contributor.authorXing, Shu Ning-
dc.contributor.authorFan, Zi Quan-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:25Z-
dc.date.available2024-04-17T07:03:25Z-
dc.date.issued2009-
dc.identifier.citationZhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2009, v. 32, n. 8, p. 1259-1261-
dc.identifier.issn1001-4454-
dc.identifier.urihttp://hdl.handle.net/10722/342381-
dc.description.abstractOBJECTIVE: To observe the activities of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose reductase (AR) by a screening model of aldose reductase inhibitor (ARI) in vitro. METHODS: The inhibition of AR by baicalin, berberine and Astragalus polysaccharides and positive drug (Epalrestat) in different concentrations were evaluated, and their combinative effects were studied according to orthogonal t design. RESULTS: Baicalin and berberine had remarkable inhibitory effects on AR, the inhibitory rates were (88.4 +/- 7.4)% and (69.0 +/- 9.4)% at the concentration of 300 microg/mL. However, the combinative effect of the inhibition on AR by the two compounds was antagonistic action. Astragalus polysaccharides had no activity of inhibition on AR. CONCLUSION: Baicalin and berberine are the potential AR inhibitors as they can inhibit the activity of AR in vitro.-
dc.languageeng-
dc.relation.ispartofZhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials-
dc.titleStudy on effects of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose reductase in vitro-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19960952-
dc.identifier.scopuseid_2-s2.0-77957305003-
dc.identifier.volume32-
dc.identifier.issue8-
dc.identifier.spage1259-
dc.identifier.epage1261-

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