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Article: GC/MS-based urinary metabolomics reveals systematic differences in metabolism and ethanol response between Sprague-Dawley and Wistar rats

TitleGC/MS-based urinary metabolomics reveals systematic differences in metabolism and ethanol response between Sprague-Dawley and Wistar rats
Authors
KeywordsEthanol intervention
GC/MS
Metabolomics
Sprague-Dawley rats
Systematic difference
Wistar rats
Issue Date2011
Citation
Metabolomics, 2011, v. 7, n. 3, p. 363-374 How to Cite?
AbstractMetabolic differences of experimental animals contribute to pharmacological variations. Sprague-Dawley (SD) and Wistar rats are commonly used experimental rats with similar genetic background, and considered interchangeable in practical researches. In this study, we present the urinary metabolomics results, based on gas chromatography coupled to mass spectrometry (GC/MS), which reveal the systematic metabolic differences between SD and Wistar rats under different perturbations such as fasting, feeding, and consecutive acute ethanol interventions. The different metabotypes between the two strains of rats involve a number of metabolic pathways and symbiotic gut microflora. SD rats exhibited higher individualized metabolic variations in the fasting and feeding states, and a stronger ability to recover from an altered metabolic profile with less hepatic injury from the consecutive ethanol exposure, as compared to Wistar rats. In summary, the GC/MS-based urinary metabolomics studies demonstrated an intrinsic metabolic difference between SD and Wistar rats, which warrants consideration in experimental design using these animal strains. © 2010 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/342393
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 0.740
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, Xianfu-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorZhou, Mingmei-
dc.contributor.authorLin, Jingchao-
dc.contributor.authorQiu, Yunping-
dc.contributor.authorSu, Mingming-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:30Z-
dc.date.available2024-04-17T07:03:30Z-
dc.date.issued2011-
dc.identifier.citationMetabolomics, 2011, v. 7, n. 3, p. 363-374-
dc.identifier.issn1573-3882-
dc.identifier.urihttp://hdl.handle.net/10722/342393-
dc.description.abstractMetabolic differences of experimental animals contribute to pharmacological variations. Sprague-Dawley (SD) and Wistar rats are commonly used experimental rats with similar genetic background, and considered interchangeable in practical researches. In this study, we present the urinary metabolomics results, based on gas chromatography coupled to mass spectrometry (GC/MS), which reveal the systematic metabolic differences between SD and Wistar rats under different perturbations such as fasting, feeding, and consecutive acute ethanol interventions. The different metabotypes between the two strains of rats involve a number of metabolic pathways and symbiotic gut microflora. SD rats exhibited higher individualized metabolic variations in the fasting and feeding states, and a stronger ability to recover from an altered metabolic profile with less hepatic injury from the consecutive ethanol exposure, as compared to Wistar rats. In summary, the GC/MS-based urinary metabolomics studies demonstrated an intrinsic metabolic difference between SD and Wistar rats, which warrants consideration in experimental design using these animal strains. © 2010 Springer Science+Business Media, LLC.-
dc.languageeng-
dc.relation.ispartofMetabolomics-
dc.subjectEthanol intervention-
dc.subjectGC/MS-
dc.subjectMetabolomics-
dc.subjectSprague-Dawley rats-
dc.subjectSystematic difference-
dc.subjectWistar rats-
dc.titleGC/MS-based urinary metabolomics reveals systematic differences in metabolism and ethanol response between Sprague-Dawley and Wistar rats-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11306-010-0252-5-
dc.identifier.scopuseid_2-s2.0-80051664076-
dc.identifier.volume7-
dc.identifier.issue3-
dc.identifier.spage363-
dc.identifier.epage374-
dc.identifier.eissn1573-3890-
dc.identifier.isiWOS:000293912300005-

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