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Article: Host-gut microbiota metabolic interactions

TitleHost-gut microbiota metabolic interactions
Authors
Nicholson, Jeremy K.Holmes, ElaineKinross, JamesBurcelin, RemyGibson, GlennJia, WeiPettersson, Sven
Issue Date2012
Citation
Science, 2012, v. 336, n. 6086, p. 1262-1267 How to Cite?
DOI: http://dx.doi.org/10.1126/science.1223813
AbstractThe composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
Persistent Identifierhttp://hdl.handle.net/10722/342414
ISSN
0036-8075
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
ISI Accession Number ID
WOS:000304905300035

 

DC FieldValueLanguage
dc.contributor.authorNicholson, Jeremy K.-
dc.contributor.authorHolmes, Elaine-
dc.contributor.authorKinross, James-
dc.contributor.authorBurcelin, Remy-
dc.contributor.authorGibson, Glenn-
dc.contributor.authorJia, Wei-
dc.contributor.authorPettersson, Sven-
dc.date.accessioned2024-04-17T07:03:38Z-
dc.date.available2024-04-17T07:03:38Z-
dc.date.issued2012-
dc.identifier.citationScience, 2012, v. 336, n. 6086, p. 1262-1267-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/342414-
dc.description.abstractThe composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.-
dc.languageeng-
dc.relation.ispartofScience-
dc.titleHost-gut microbiota metabolic interactions-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1126/science.1223813-
dc.identifier.scopuseid_2-s2.0-84861978076-
dc.identifier.volume336-
dc.identifier.issue6086-
dc.identifier.spage1262-
dc.identifier.epage1267-
dc.identifier.eissn1095-9203-
dc.identifier.isiWOS:000304905300035-

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