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Article: Transcriptomic and metabonomic profiling reveal synergistic effects of quercetin and resveratrol supplementation in high fat diet fed mice

TitleTranscriptomic and metabonomic profiling reveal synergistic effects of quercetin and resveratrol supplementation in high fat diet fed mice
Authors
Keywordsfatty liver
GC/MS
high fat diet
metabonomics
quercetin
resveratrol
transcriptomics
Issue Date2012
Citation
Journal of Proteome Research, 2012, v. 11, n. 10, p. 4961-4971 How to Cite?
AbstractDietary quercetin and resveratrol have been frequently used in treating various diseases, but the underlying mechanisms are not entirely clear. Here, we report combined transcriptomic and metabonomic profiling that showed that the combined supplementation with quercetin and resveratrol produced synergistic effects on a high-fat diet-induced metabolic phenotype in mice. Histological and phenotypic improvements in serum and hepatic total cholesterol, insulin, fasting blood glucose, and HbA1c were also observed in mice receiving combined quercetin and resveratrol supplementation. This combined quercetin and resveratrol supplementation resulted in significant restoration of gene sets in functional pathways of glucose/lipid metabolism, liver function, cardiovascular system, and inflammation/immunity, which were altered by high fat diet feeding. The integration of transcriptomic and metabonomic data indicated quercetin and resveratrol supplementation enhanced processes of glycolysis and fatty acid oxidation, as well as suppressed gluconeogenesis. These alterations discovered at both the transcriptional and metabolic levels highlight the significance of combined "omics" platforms for elucidating mechanistic pathways altered by dietary polyphenols, such as quercetin and resveratrol, in a synergistic manner. © 2012 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/342429
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Mingmei-
dc.contributor.authorWang, Shidong-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorWang, Ke-
dc.contributor.authorFan, Ziquan-
dc.contributor.authorYang, Hongzhou-
dc.contributor.authorLiao, Wen-
dc.contributor.authorBao, Si-
dc.contributor.authorZhao, Linjing-
dc.contributor.authorZhang, Yinan-
dc.contributor.authorYang, Yongqing-
dc.contributor.authorQiu, Yunping-
dc.contributor.authorXie, Guoxiang-
dc.contributor.authorLi, Houkai-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:45Z-
dc.date.available2024-04-17T07:03:45Z-
dc.date.issued2012-
dc.identifier.citationJournal of Proteome Research, 2012, v. 11, n. 10, p. 4961-4971-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342429-
dc.description.abstractDietary quercetin and resveratrol have been frequently used in treating various diseases, but the underlying mechanisms are not entirely clear. Here, we report combined transcriptomic and metabonomic profiling that showed that the combined supplementation with quercetin and resveratrol produced synergistic effects on a high-fat diet-induced metabolic phenotype in mice. Histological and phenotypic improvements in serum and hepatic total cholesterol, insulin, fasting blood glucose, and HbA1c were also observed in mice receiving combined quercetin and resveratrol supplementation. This combined quercetin and resveratrol supplementation resulted in significant restoration of gene sets in functional pathways of glucose/lipid metabolism, liver function, cardiovascular system, and inflammation/immunity, which were altered by high fat diet feeding. The integration of transcriptomic and metabonomic data indicated quercetin and resveratrol supplementation enhanced processes of glycolysis and fatty acid oxidation, as well as suppressed gluconeogenesis. These alterations discovered at both the transcriptional and metabolic levels highlight the significance of combined "omics" platforms for elucidating mechanistic pathways altered by dietary polyphenols, such as quercetin and resveratrol, in a synergistic manner. © 2012 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectfatty liver-
dc.subjectGC/MS-
dc.subjecthigh fat diet-
dc.subjectmetabonomics-
dc.subjectquercetin-
dc.subjectresveratrol-
dc.subjecttranscriptomics-
dc.titleTranscriptomic and metabonomic profiling reveal synergistic effects of quercetin and resveratrol supplementation in high fat diet fed mice-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr3004826-
dc.identifier.pmid22916952-
dc.identifier.scopuseid_2-s2.0-84867453251-
dc.identifier.volume11-
dc.identifier.issue10-
dc.identifier.spage4961-
dc.identifier.epage4971-
dc.identifier.eissn1535-3907-
dc.identifier.isiWOS:000309441000018-

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