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Article: Profiling of serum bile acids in a healthy chinese population using UPLC-MS/MS

TitleProfiling of serum bile acids in a healthy chinese population using UPLC-MS/MS
Authors
Keywordsage
bile acids
BMI
gender
LC-TQMS
metabonomics
Issue Date2015
Citation
Journal of Proteome Research, 2015, v. 14, n. 2, p. 850-859 How to Cite?
AbstractBile acids (BAs) are a group of important physiological agents for cholesterol metabolism, intestinal nutrient absorption, and biliary secretion of lipids, toxic metabolites, and xenobiotics. Extensive research in the last two decades has unveiled new functions of BAs as signaling molecules and metabolic regulators that modulate hepatic lipid, glucose, and energy homeostasis through the activation of nuclear receptors and G-protein-coupled receptor signaling in gut-liver metabolic axis involving host-gut microbial co-metabolism. Therefore, investigation of serum BA profiles, in healthy human male and female subjects with a wide range of age and body mass index (BMI), will provide important baseline information on the BA physiology as well as metabolic homeostasis among human subjects that are regulated by two sets of genome, host genome, and symbiotic microbiome. Previous reports on age- or gender-related changes on BA profiles in animals and human showed inconsistent results, and the information acquired from various studies was highly fragmentary. Here we profiled the serum BAs in a large population of healthy participants (n = 502) and examined the impact of age, gender, and BMI on serum BA concentrations and compositions using a targeted metabonomics approach with ultraperformance liquid chromatography triple-quadrupole mass spectrometry. We found that the BA profiles were dependent on gender, age, and BMI among study subjects. The total BAs were significantly higher in males than in females (p < 0.05) and higher in obese females than in lean females (p < 0.05). The difference in BA profiles between male and female subjects was decreased at age of 50-70 years, while the difference in BA profiles between lean and obese increased for subjects aged 50-70 years. The study provides a comprehensive understanding of the BA profiles in healthy subjects and highlights the need to take into account age, gender, and BMI differences when investigating pathophysiological changes of BAs resulting from gastrointestinal diseases.
Persistent Identifierhttp://hdl.handle.net/10722/342486
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXie, Guoxiang-
dc.contributor.authorWang, Yixing-
dc.contributor.authorWang, Xiaoning-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorChen, Tianlu-
dc.contributor.authorNi, Yan-
dc.contributor.authorWong, Linda-
dc.contributor.authorZhang, Hua-
dc.contributor.authorZhang, Jue-
dc.contributor.authorLiu, Chang-
dc.contributor.authorLiu, Ping-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:04:09Z-
dc.date.available2024-04-17T07:04:09Z-
dc.date.issued2015-
dc.identifier.citationJournal of Proteome Research, 2015, v. 14, n. 2, p. 850-859-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342486-
dc.description.abstractBile acids (BAs) are a group of important physiological agents for cholesterol metabolism, intestinal nutrient absorption, and biliary secretion of lipids, toxic metabolites, and xenobiotics. Extensive research in the last two decades has unveiled new functions of BAs as signaling molecules and metabolic regulators that modulate hepatic lipid, glucose, and energy homeostasis through the activation of nuclear receptors and G-protein-coupled receptor signaling in gut-liver metabolic axis involving host-gut microbial co-metabolism. Therefore, investigation of serum BA profiles, in healthy human male and female subjects with a wide range of age and body mass index (BMI), will provide important baseline information on the BA physiology as well as metabolic homeostasis among human subjects that are regulated by two sets of genome, host genome, and symbiotic microbiome. Previous reports on age- or gender-related changes on BA profiles in animals and human showed inconsistent results, and the information acquired from various studies was highly fragmentary. Here we profiled the serum BAs in a large population of healthy participants (n = 502) and examined the impact of age, gender, and BMI on serum BA concentrations and compositions using a targeted metabonomics approach with ultraperformance liquid chromatography triple-quadrupole mass spectrometry. We found that the BA profiles were dependent on gender, age, and BMI among study subjects. The total BAs were significantly higher in males than in females (p < 0.05) and higher in obese females than in lean females (p < 0.05). The difference in BA profiles between male and female subjects was decreased at age of 50-70 years, while the difference in BA profiles between lean and obese increased for subjects aged 50-70 years. The study provides a comprehensive understanding of the BA profiles in healthy subjects and highlights the need to take into account age, gender, and BMI differences when investigating pathophysiological changes of BAs resulting from gastrointestinal diseases.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectage-
dc.subjectbile acids-
dc.subjectBMI-
dc.subjectgender-
dc.subjectLC-TQMS-
dc.subjectmetabonomics-
dc.titleProfiling of serum bile acids in a healthy chinese population using UPLC-MS/MS-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr500920q-
dc.identifier.pmid25581415-
dc.identifier.scopuseid_2-s2.0-84922653598-
dc.identifier.volume14-
dc.identifier.issue2-
dc.identifier.spage850-
dc.identifier.epage859-
dc.identifier.eissn1535-3907-
dc.identifier.isiWOS:000349276400025-

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