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- Publisher Website: 10.1021/acs.jproteome.6b00984
- Scopus: eid_2-s2.0-85019015627
- PMID: 28378586
- WOS: WOS:000401044600008
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Article: Gut Microbiota Modulation Attenuated the Hypolipidemic Effect of Simvastatin in High-Fat/Cholesterol-Diet Fed Mice
Title | Gut Microbiota Modulation Attenuated the Hypolipidemic Effect of Simvastatin in High-Fat/Cholesterol-Diet Fed Mice |
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Authors | |
Keywords | antibiotic gut microbiota hypolipidemic effect metabolomics simvastatin |
Issue Date | 2017 |
Citation | Journal of Proteome Research, 2017, v. 16, n. 5, p. 1900-1910 How to Cite? |
Abstract | The hypolipidemic effect of simvastatin varies greatly among patients. In the current study, we investigated the gut microbial-involved mechanisms underlying the different responses to simvastatin. Male C57BL/6J mice were divided into control (Con), high-fat/cholesterol diet (HFD), antibiotic (AB), simvastatin (SV) and antibiotic-simvastatin (AB-SV) groups, respectively. At the end of the experiment, serum samples were collected for lipids and metabolomic analysis, and liver tissues for histology, gene and protein expression analysis. The results showed that antibiotic treatment not only altered the composition of gut microbiota, but attenuated the hypolipidemic effect of SV. A total of 16 differential metabolites between SV and HFD groups were identified with metabolomics, while most of them showed no statistical differences between AB-SV and HFD groups, and similar changes were also observed in bile acids profile. The expressions of several genes and proteins involved in regulating bile acids synthesis were significantly reversed by SV, but not AB-SV in HFD fed mice. In summary, our current study indicated that the hypolipidemic effect of SV was correlated with the composition of the gut microbiota, and the attenuated hypolipidemic effect of SV by gut microbiota modulation was associated with a suppression of bile acids synthesis from cholesterol. |
Persistent Identifier | http://hdl.handle.net/10722/342539 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.299 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | He, Xuyun | - |
dc.contributor.author | Zheng, Ningning | - |
dc.contributor.author | He, Jiaojiao | - |
dc.contributor.author | Liu, Can | - |
dc.contributor.author | Feng, Jing | - |
dc.contributor.author | Jia, Wei | - |
dc.contributor.author | Li, Houkai | - |
dc.date.accessioned | 2024-04-17T07:04:32Z | - |
dc.date.available | 2024-04-17T07:04:32Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Journal of Proteome Research, 2017, v. 16, n. 5, p. 1900-1910 | - |
dc.identifier.issn | 1535-3893 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342539 | - |
dc.description.abstract | The hypolipidemic effect of simvastatin varies greatly among patients. In the current study, we investigated the gut microbial-involved mechanisms underlying the different responses to simvastatin. Male C57BL/6J mice were divided into control (Con), high-fat/cholesterol diet (HFD), antibiotic (AB), simvastatin (SV) and antibiotic-simvastatin (AB-SV) groups, respectively. At the end of the experiment, serum samples were collected for lipids and metabolomic analysis, and liver tissues for histology, gene and protein expression analysis. The results showed that antibiotic treatment not only altered the composition of gut microbiota, but attenuated the hypolipidemic effect of SV. A total of 16 differential metabolites between SV and HFD groups were identified with metabolomics, while most of them showed no statistical differences between AB-SV and HFD groups, and similar changes were also observed in bile acids profile. The expressions of several genes and proteins involved in regulating bile acids synthesis were significantly reversed by SV, but not AB-SV in HFD fed mice. In summary, our current study indicated that the hypolipidemic effect of SV was correlated with the composition of the gut microbiota, and the attenuated hypolipidemic effect of SV by gut microbiota modulation was associated with a suppression of bile acids synthesis from cholesterol. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Proteome Research | - |
dc.subject | antibiotic | - |
dc.subject | gut microbiota | - |
dc.subject | hypolipidemic effect | - |
dc.subject | metabolomics | - |
dc.subject | simvastatin | - |
dc.title | Gut Microbiota Modulation Attenuated the Hypolipidemic Effect of Simvastatin in High-Fat/Cholesterol-Diet Fed Mice | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acs.jproteome.6b00984 | - |
dc.identifier.pmid | 28378586 | - |
dc.identifier.scopus | eid_2-s2.0-85019015627 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1900 | - |
dc.identifier.epage | 1910 | - |
dc.identifier.eissn | 1535-3907 | - |
dc.identifier.isi | WOS:000401044600008 | - |