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- Publisher Website: 10.1038/ncomms15129
- Scopus: eid_2-s2.0-85019685443
- PMID: 28541302
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Article: The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
Title | The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion |
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Authors | |
Issue Date | 2017 |
Citation | Nature Communications, 2017, v. 8, article no. 15129 How to Cite? |
Abstract | Long noncoding RNAs play a pivotal role in T-helper cell development but little is known about their roles in Treg differentiation and functions during the progression of hepatocellular carcinoma (HCC). Here, we show that lnc-epidermal growth factor receptor (EGFR) upregulation in Tregs correlates positively with the tumour size and expression of EGFR/Foxp3, but negatively with IFN-3 expression in patients and xenografted mouse models. Lnc-EGFR stimulates Treg differentiation, suppresses CTL activity and promotes HCC growth in an EGFR-dependent manner. Mechanistically, lnc-EGFR specifically binds to EGFR and blocks its interaction with and ubiquitination by c-CBL, stabilizing it and augmenting activation of itself and its downstream AP-1/NF-AT1 axis, which in turn elicits EGFR expression. Lnc-EGFR links an immunosuppressive state to cancer by promoting Treg cell differentiation, thus offering a potential therapeutic target for HCC. |
Persistent Identifier | http://hdl.handle.net/10722/342540 |
DC Field | Value | Language |
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dc.contributor.author | Jiang, Runqiu | - |
dc.contributor.author | Tang, Junwei | - |
dc.contributor.author | Chen, Yun | - |
dc.contributor.author | Deng, Lei | - |
dc.contributor.author | Ji, Jie | - |
dc.contributor.author | Xie, Yu | - |
dc.contributor.author | Wang, Ke | - |
dc.contributor.author | Jia, Wei | - |
dc.contributor.author | Chu, Wen Ming | - |
dc.contributor.author | Sun, Beicheng | - |
dc.date.accessioned | 2024-04-17T07:04:32Z | - |
dc.date.available | 2024-04-17T07:04:32Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Nature Communications, 2017, v. 8, article no. 15129 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342540 | - |
dc.description.abstract | Long noncoding RNAs play a pivotal role in T-helper cell development but little is known about their roles in Treg differentiation and functions during the progression of hepatocellular carcinoma (HCC). Here, we show that lnc-epidermal growth factor receptor (EGFR) upregulation in Tregs correlates positively with the tumour size and expression of EGFR/Foxp3, but negatively with IFN-3 expression in patients and xenografted mouse models. Lnc-EGFR stimulates Treg differentiation, suppresses CTL activity and promotes HCC growth in an EGFR-dependent manner. Mechanistically, lnc-EGFR specifically binds to EGFR and blocks its interaction with and ubiquitination by c-CBL, stabilizing it and augmenting activation of itself and its downstream AP-1/NF-AT1 axis, which in turn elicits EGFR expression. Lnc-EGFR links an immunosuppressive state to cancer by promoting Treg cell differentiation, thus offering a potential therapeutic target for HCC. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Communications | - |
dc.title | The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/ncomms15129 | - |
dc.identifier.pmid | 28541302 | - |
dc.identifier.scopus | eid_2-s2.0-85019685443 | - |
dc.identifier.volume | 8 | - |
dc.identifier.spage | article no. 15129 | - |
dc.identifier.epage | article no. 15129 | - |
dc.identifier.eissn | 2041-1723 | - |