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- Publisher Website: 10.1002/cpt.784
- Scopus: eid_2-s2.0-85043458333
- PMID: 28675423
- WOS: WOS:000427114900032
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Article: Poly-pharmacokinetic Study of a Multicomponent Herbal Medicine in Healthy Chinese Volunteers
Title | Poly-pharmacokinetic Study of a Multicomponent Herbal Medicine in Healthy Chinese Volunteers |
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Authors | |
Issue Date | 2018 |
Citation | Clinical Pharmacology and Therapeutics, 2018, v. 103, n. 4, p. 692-702 How to Cite? |
Abstract | The advent of mass spectrometry-based analytical technologies coupled with multivariate statistical methods offer tremendous new opportunities for understanding the pharmacokinetics (PKs) of multicomponent herbal medicines (HMs). We recently proposed a poly-PK strategy to characterize the concentration-time profile and the metabolic response profile of multicomponent HMs using an integrated phytochemical and metabolomics approach. Here, we provided the first example of the poly-PK strategy, in which we simultaneously characterized the PK as well as the metabolic response profiles of a Chinese HM, Huangqi decoction (HQD, consisting of Radix Astragali and Radix Glycyrrhizae), in healthy Chinese volunteers. Using the poly-PK approach, we identified 56 HQD-derived compounds and 292 biotransformed HQD metabolites in human plasma. Additionally, we acquired the concentration-time profiles of these plasma HQD metabolites and correlated them with a plasma metabolomics profile consisting of 166 human endogenous metabolites that were significantly altered in response to HQD intervention. |
Persistent Identifier | http://hdl.handle.net/10722/342561 |
ISSN | 2021 Impact Factor: 6.903 2020 SCImago Journal Rankings: 1.941 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xie, Guoxiang | - |
dc.contributor.author | Wang, Shouli | - |
dc.contributor.author | Zhang, Hua | - |
dc.contributor.author | Zhao, Aihua | - |
dc.contributor.author | Liu, Jiajian | - |
dc.contributor.author | Ma, Yueming | - |
dc.contributor.author | Lan, Ke | - |
dc.contributor.author | Ni, Yan | - |
dc.contributor.author | Liu, Changxiao | - |
dc.contributor.author | Liu, Ping | - |
dc.contributor.author | Chen, Tianlu | - |
dc.contributor.author | Jia, Wei | - |
dc.date.accessioned | 2024-04-17T07:04:40Z | - |
dc.date.available | 2024-04-17T07:04:40Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Clinical Pharmacology and Therapeutics, 2018, v. 103, n. 4, p. 692-702 | - |
dc.identifier.issn | 0009-9236 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342561 | - |
dc.description.abstract | The advent of mass spectrometry-based analytical technologies coupled with multivariate statistical methods offer tremendous new opportunities for understanding the pharmacokinetics (PKs) of multicomponent herbal medicines (HMs). We recently proposed a poly-PK strategy to characterize the concentration-time profile and the metabolic response profile of multicomponent HMs using an integrated phytochemical and metabolomics approach. Here, we provided the first example of the poly-PK strategy, in which we simultaneously characterized the PK as well as the metabolic response profiles of a Chinese HM, Huangqi decoction (HQD, consisting of Radix Astragali and Radix Glycyrrhizae), in healthy Chinese volunteers. Using the poly-PK approach, we identified 56 HQD-derived compounds and 292 biotransformed HQD metabolites in human plasma. Additionally, we acquired the concentration-time profiles of these plasma HQD metabolites and correlated them with a plasma metabolomics profile consisting of 166 human endogenous metabolites that were significantly altered in response to HQD intervention. | - |
dc.language | eng | - |
dc.relation.ispartof | Clinical Pharmacology and Therapeutics | - |
dc.title | Poly-pharmacokinetic Study of a Multicomponent Herbal Medicine in Healthy Chinese Volunteers | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/cpt.784 | - |
dc.identifier.pmid | 28675423 | - |
dc.identifier.scopus | eid_2-s2.0-85043458333 | - |
dc.identifier.volume | 103 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 692 | - |
dc.identifier.epage | 702 | - |
dc.identifier.eissn | 1532-6535 | - |
dc.identifier.isi | WOS:000427114900032 | - |