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Article: Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid

TitleVancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid
Authors
Keywords2-Hydroxybutyric acid
Acetaminophen
Gut microbiota
Liver injury
revealed
Vancomycin
Issue Date2020
Citation
Journal of Pharmaceutical Analysis, 2020, v. 10, n. 6, p. 560-570 How to Cite?
AbstractLiver injury caused by acetaminophen (AP) overdose is a leading public health problem. Although AP-induced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone (NAPQI), a toxic metabolite of AP, resulting in cell damage, emerging evidence indicates that AP-induced liver injury is also associated with gut microbiota. However, the gut microbiota-involved mechanism remains largely unknown. In our study, we found that vancomycin (Vac) pretreatment (100 mg/kg, twice a day for 4 days) attenuated AP-induced liver injury, altered the composition of gut microbiota, and changed serum metabolic profile. Moreover, we identified Vac pretreatment elevated cecum and serum 2-hydroxybutyric acid (2-HB), which ameliorated AP-induced cell damage and liver injury in mice by reducing AP bioavailability and elevating GSH levels. Our current results revealed the novel role of 2-HB in protecting AP-induced liver injury and add new evidence for gut microbiota in affecting AP toxicity.
Persistent Identifierhttp://hdl.handle.net/10722/342596
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 1.068
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZheng, Ningning-
dc.contributor.authorGu, Yu-
dc.contributor.authorHong, Ying-
dc.contributor.authorSheng, Lili-
dc.contributor.authorChen, Linlin-
dc.contributor.authorZhang, Feng-
dc.contributor.authorHou, Jie-
dc.contributor.authorZhang, Weidong-
dc.contributor.authorZhang, Zean-
dc.contributor.authorJia, Wei-
dc.contributor.authorLi, Houkai-
dc.date.accessioned2024-04-17T07:04:55Z-
dc.date.available2024-04-17T07:04:55Z-
dc.date.issued2020-
dc.identifier.citationJournal of Pharmaceutical Analysis, 2020, v. 10, n. 6, p. 560-570-
dc.identifier.issn2095-1779-
dc.identifier.urihttp://hdl.handle.net/10722/342596-
dc.description.abstractLiver injury caused by acetaminophen (AP) overdose is a leading public health problem. Although AP-induced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone (NAPQI), a toxic metabolite of AP, resulting in cell damage, emerging evidence indicates that AP-induced liver injury is also associated with gut microbiota. However, the gut microbiota-involved mechanism remains largely unknown. In our study, we found that vancomycin (Vac) pretreatment (100 mg/kg, twice a day for 4 days) attenuated AP-induced liver injury, altered the composition of gut microbiota, and changed serum metabolic profile. Moreover, we identified Vac pretreatment elevated cecum and serum 2-hydroxybutyric acid (2-HB), which ameliorated AP-induced cell damage and liver injury in mice by reducing AP bioavailability and elevating GSH levels. Our current results revealed the novel role of 2-HB in protecting AP-induced liver injury and add new evidence for gut microbiota in affecting AP toxicity.-
dc.languageeng-
dc.relation.ispartofJournal of Pharmaceutical Analysis-
dc.subject2-Hydroxybutyric acid-
dc.subjectAcetaminophen-
dc.subjectGut microbiota-
dc.subjectLiver injury-
dc.subjectrevealed-
dc.subjectVancomycin-
dc.titleVancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jpha.2019.11.003-
dc.identifier.scopuseid_2-s2.0-85076865214-
dc.identifier.volume10-
dc.identifier.issue6-
dc.identifier.spage560-
dc.identifier.epage570-
dc.identifier.isiWOS:000604958600006-

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