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Article: Effects of vaginal microbiota transfer on the neurodevelopment and microbiome of cesarean-born infants: A blinded randomized controlled trial

TitleEffects of vaginal microbiota transfer on the neurodevelopment and microbiome of cesarean-born infants: A blinded randomized controlled trial
Authors
Keywordscesarean section
gut metabolome
gut microbiome
infants
neurodevelopment
randomized controlled trial
vaginal microbiota transfer
Issue Date2023
Citation
Cell Host and Microbe, 2023, v. 31, n. 7, p. 1232-1247.e5 How to Cite?
AbstractThe microbiomes of cesarean-born infants differ from vaginally delivered infants and are associated with increased disease risks. Vaginal microbiota transfer (VMT) to newborns may reverse C-section-related microbiome disturbances. Here, we evaluated the effect of VMT by exposing newborns to maternal vaginal fluids and assessing neurodevelopment, as well as the fecal microbiota and metabolome. Sixty-eight cesarean-delivered infants were randomly assigned a VMT or saline gauze intervention immediately after delivery in a triple-blind manner (ChiCTR2000031326). Adverse events were not significantly different between the two groups. Infant neurodevelopment, as measured by the Ages and Stages Questionnaire (ASQ-3) score at 6 months, was significantly higher with VMT than saline. VMT significantly accelerated gut microbiota maturation and regulated levels of certain fecal metabolites and metabolic functions, including carbohydrate, energy, and amino acid metabolisms, within 42 days after birth. Overall, VMT is likely safe and may partially normalize neurodevelopment and the fecal microbiome in cesarean-delivered infants.
Persistent Identifierhttp://hdl.handle.net/10722/342674
ISSN
2023 Impact Factor: 20.6
2023 SCImago Journal Rankings: 7.760
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Lepeng-
dc.contributor.authorQiu, Wen-
dc.contributor.authorWang, Jie-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorZhou, Chuhui-
dc.contributor.authorSun, Tao-
dc.contributor.authorXiong, Ziyu-
dc.contributor.authorCao, Peihua-
dc.contributor.authorShen, Wei-
dc.contributor.authorChen, Jingfen-
dc.contributor.authorLai, Xiaolu-
dc.contributor.authorZhao, Liu hong-
dc.contributor.authorWu, Yue-
dc.contributor.authorLi, Meng-
dc.contributor.authorQiu, Feng-
dc.contributor.authorYu, Yanhong-
dc.contributor.authorXu, Zhenjiang Zech-
dc.contributor.authorZhou, Hongwei-
dc.contributor.authorJia, Wei-
dc.contributor.authorLiao, Yan-
dc.contributor.authorRetnakaran, Ravi-
dc.contributor.authorKrewski, Daniel-
dc.contributor.authorWen, Shi Wu-
dc.contributor.authorClemente, Jose C.-
dc.contributor.authorChen, Tianlu-
dc.contributor.authorXie, Ri hua-
dc.contributor.authorHe, Yan-
dc.date.accessioned2024-04-17T07:05:27Z-
dc.date.available2024-04-17T07:05:27Z-
dc.date.issued2023-
dc.identifier.citationCell Host and Microbe, 2023, v. 31, n. 7, p. 1232-1247.e5-
dc.identifier.issn1931-3128-
dc.identifier.urihttp://hdl.handle.net/10722/342674-
dc.description.abstractThe microbiomes of cesarean-born infants differ from vaginally delivered infants and are associated with increased disease risks. Vaginal microbiota transfer (VMT) to newborns may reverse C-section-related microbiome disturbances. Here, we evaluated the effect of VMT by exposing newborns to maternal vaginal fluids and assessing neurodevelopment, as well as the fecal microbiota and metabolome. Sixty-eight cesarean-delivered infants were randomly assigned a VMT or saline gauze intervention immediately after delivery in a triple-blind manner (ChiCTR2000031326). Adverse events were not significantly different between the two groups. Infant neurodevelopment, as measured by the Ages and Stages Questionnaire (ASQ-3) score at 6 months, was significantly higher with VMT than saline. VMT significantly accelerated gut microbiota maturation and regulated levels of certain fecal metabolites and metabolic functions, including carbohydrate, energy, and amino acid metabolisms, within 42 days after birth. Overall, VMT is likely safe and may partially normalize neurodevelopment and the fecal microbiome in cesarean-delivered infants.-
dc.languageeng-
dc.relation.ispartofCell Host and Microbe-
dc.subjectcesarean section-
dc.subjectgut metabolome-
dc.subjectgut microbiome-
dc.subjectinfants-
dc.subjectneurodevelopment-
dc.subjectrandomized controlled trial-
dc.subjectvaginal microbiota transfer-
dc.titleEffects of vaginal microbiota transfer on the neurodevelopment and microbiome of cesarean-born infants: A blinded randomized controlled trial-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.chom.2023.05.022-
dc.identifier.pmid37327780-
dc.identifier.scopuseid_2-s2.0-85164846920-
dc.identifier.volume31-
dc.identifier.issue7-
dc.identifier.spage1232-
dc.identifier.epage1247.e5-
dc.identifier.eissn1934-6069-
dc.identifier.isiWOS:001045261500001-

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