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- Publisher Website: 10.1155/2013/836179
- Scopus: eid_2-s2.0-84874524154
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Article: A metabolomics-based strategy for the quality control of traditional chinese medicine: Shengmai injection as a case study
Title | A metabolomics-based strategy for the quality control of traditional chinese medicine: Shengmai injection as a case study |
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Authors | |
Issue Date | 2013 |
Citation | Evidence-based Complementary and Alternative Medicine, 2013, v. 2013, article no. 836179 How to Cite? |
Abstract | Quality control of traditional Chinese medicines (TCMs) used clinically is becoming a challenge and has limited the development of TCM due to the high variability in concentration levels of active ingredients and markers as well as the lack of well-established criteria. Using Shengmai injection, which is a well-established TCM, as an example, we developed an integrated profiling approach that simultaneously captures the entire spectrum of ingredients and quantitatively determines the levels of seven key ingredients in the TCM product. A multivariate statistical model was constructed to establish a "seven-marker-" based quality standard that qualified the majority of samples in this study. This newly developed strategy showed that a panel of key ingredients or markers in the TCM product were relatively consistent within a statistically acceptable range. Therefore, this metabolomics-based approach will complement the current quality control standard using the concentration of several key ingredients or their total content and help improve the consistency and clinic efficacy of TCM products. © 2013 Xiaodong Li et al. |
Persistent Identifier | http://hdl.handle.net/10722/342735 |
ISSN | 2021 Impact Factor: 2.650 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, Xiaodong | - |
dc.contributor.author | Chen, Huiyuan | - |
dc.contributor.author | Jia, Wei | - |
dc.contributor.author | Xie, Guoxiang | - |
dc.date.accessioned | 2024-04-17T07:05:53Z | - |
dc.date.available | 2024-04-17T07:05:53Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Evidence-based Complementary and Alternative Medicine, 2013, v. 2013, article no. 836179 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | http://hdl.handle.net/10722/342735 | - |
dc.description.abstract | Quality control of traditional Chinese medicines (TCMs) used clinically is becoming a challenge and has limited the development of TCM due to the high variability in concentration levels of active ingredients and markers as well as the lack of well-established criteria. Using Shengmai injection, which is a well-established TCM, as an example, we developed an integrated profiling approach that simultaneously captures the entire spectrum of ingredients and quantitatively determines the levels of seven key ingredients in the TCM product. A multivariate statistical model was constructed to establish a "seven-marker-" based quality standard that qualified the majority of samples in this study. This newly developed strategy showed that a panel of key ingredients or markers in the TCM product were relatively consistent within a statistically acceptable range. Therefore, this metabolomics-based approach will complement the current quality control standard using the concentration of several key ingredients or their total content and help improve the consistency and clinic efficacy of TCM products. © 2013 Xiaodong Li et al. | - |
dc.language | eng | - |
dc.relation.ispartof | Evidence-based Complementary and Alternative Medicine | - |
dc.title | A metabolomics-based strategy for the quality control of traditional chinese medicine: Shengmai injection as a case study | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1155/2013/836179 | - |
dc.identifier.scopus | eid_2-s2.0-84874524154 | - |
dc.identifier.volume | 2013 | - |
dc.identifier.spage | article no. 836179 | - |
dc.identifier.epage | article no. 836179 | - |
dc.identifier.eissn | 1741-4288 | - |
dc.identifier.isi | WOS:000314416100001 | - |