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Article: A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer

TitleA review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer
Authors
KeywordsColorectal cancer
Conventional medicines
Herbs
Natural products
Network pharmacology
Obesity
Obesity-associated colorectal cancer
Target prediction
Issue Date2022
Citation
Pharmacological Research, 2022, v. 175, article no. 106031 How to Cite?
AbstractColorectal cancer (CRC) is the third leading cause of cancer death worldwide. Obesity has been proven to be closely related to colorectal carcinogenesis. This review summarized the potential underlying mechanisms linking obesity to CRC in different aspects, including energy metabolism, inflammation, activities of adipokines and hormones. Furthermore, the potential therapeutic targets of obesity-associated CRC were predicted using network-based target analysis, with total predicted pathways not only containing previously reported pathways, but also putative signaling pathways pending for investigation. In addition, the current conventional therapeutic treatment options, plus the potential use of herbs and natural products in the management of obesity-associated CRC were also discussed. Taken together, the aim of this review article is to provide strong theoretical basis for future drug development, particularly herbs and natural products, in obesity-associated CRC.
Persistent Identifierhttp://hdl.handle.net/10722/342978
ISSN
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.160

 

DC FieldValueLanguage
dc.contributor.authorYang, Huihai-
dc.contributor.authorYue, Grace Gar Lee-
dc.contributor.authorLeung, Ping Chung-
dc.contributor.authorWong, Chun Kwok-
dc.contributor.authorLau, Clara Bik San-
dc.date.accessioned2024-05-10T09:04:29Z-
dc.date.available2024-05-10T09:04:29Z-
dc.date.issued2022-
dc.identifier.citationPharmacological Research, 2022, v. 175, article no. 106031-
dc.identifier.issn1043-6618-
dc.identifier.urihttp://hdl.handle.net/10722/342978-
dc.description.abstractColorectal cancer (CRC) is the third leading cause of cancer death worldwide. Obesity has been proven to be closely related to colorectal carcinogenesis. This review summarized the potential underlying mechanisms linking obesity to CRC in different aspects, including energy metabolism, inflammation, activities of adipokines and hormones. Furthermore, the potential therapeutic targets of obesity-associated CRC were predicted using network-based target analysis, with total predicted pathways not only containing previously reported pathways, but also putative signaling pathways pending for investigation. In addition, the current conventional therapeutic treatment options, plus the potential use of herbs and natural products in the management of obesity-associated CRC were also discussed. Taken together, the aim of this review article is to provide strong theoretical basis for future drug development, particularly herbs and natural products, in obesity-associated CRC.-
dc.languageeng-
dc.relation.ispartofPharmacological Research-
dc.subjectColorectal cancer-
dc.subjectConventional medicines-
dc.subjectHerbs-
dc.subjectNatural products-
dc.subjectNetwork pharmacology-
dc.subjectObesity-
dc.subjectObesity-associated colorectal cancer-
dc.subjectTarget prediction-
dc.titleA review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.phrs.2021.106031-
dc.identifier.pmid34896542-
dc.identifier.scopuseid_2-s2.0-85121252552-
dc.identifier.volume175-
dc.identifier.spagearticle no. 106031-
dc.identifier.epagearticle no. 106031-
dc.identifier.eissn1096-1186-

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