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- Publisher Website: 10.1021/ol8010503
- Scopus: eid_2-s2.0-52049092803
- PMID: 18557625
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Article: Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent
Title | Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent |
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Authors | |
Issue Date | 2008 |
Citation | Organic Letters, 2008, v. 10, n. 14, p. 3145-3148 How to Cite? |
Abstract | (Chemical Equation Presented) A pseudo-1,4′-N-linked disaccharide, pseudoacarviosin 5, was constructed via a key palladium-catalyzed coupling reaction of pseudoglycosyl chloride 8 (prepared from d-glucose via a novel direct intramolecular aldol addition in 12 steps) and pseudo-4-amino-4,6- dideoxy-α-d-glucose 9 (prepared from l-arabinose via an unusual trans-fused isoxazolidine-selective intramolecular nitrone-alkene cycloaddition in 11 steps). Pseudoacarviosin 5 has been shown to be a potent inhibitor of α-glucosidases, particularly the intestinal mucosal enzymes sucrase and glucoamylase of relevance to blood glucose control. © 2008 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/343037 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.245 |
DC Field | Value | Language |
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dc.contributor.author | Shing, Tony K.M. | - |
dc.contributor.author | Cheng, Hau M. | - |
dc.contributor.author | Wong, Wai F. | - |
dc.contributor.author | Kwong, Connie S.K. | - |
dc.contributor.author | Li, Jianmei | - |
dc.contributor.author | Lau, Clara B.S. | - |
dc.contributor.author | Po, Sing Leung | - |
dc.contributor.author | Cheng, Christopher H.K. | - |
dc.date.accessioned | 2024-05-10T09:04:57Z | - |
dc.date.available | 2024-05-10T09:04:57Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Organic Letters, 2008, v. 10, n. 14, p. 3145-3148 | - |
dc.identifier.issn | 1523-7060 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343037 | - |
dc.description.abstract | (Chemical Equation Presented) A pseudo-1,4′-N-linked disaccharide, pseudoacarviosin 5, was constructed via a key palladium-catalyzed coupling reaction of pseudoglycosyl chloride 8 (prepared from d-glucose via a novel direct intramolecular aldol addition in 12 steps) and pseudo-4-amino-4,6- dideoxy-α-d-glucose 9 (prepared from l-arabinose via an unusual trans-fused isoxazolidine-selective intramolecular nitrone-alkene cycloaddition in 11 steps). Pseudoacarviosin 5 has been shown to be a potent inhibitor of α-glucosidases, particularly the intestinal mucosal enzymes sucrase and glucoamylase of relevance to blood glucose control. © 2008 American Chemical Society. | - |
dc.language | eng | - |
dc.relation.ispartof | Organic Letters | - |
dc.title | Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/ol8010503 | - |
dc.identifier.pmid | 18557625 | - |
dc.identifier.scopus | eid_2-s2.0-52049092803 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 14 | - |
dc.identifier.spage | 3145 | - |
dc.identifier.epage | 3148 | - |