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- Publisher Website: 10.1038/nature08540
- Scopus: eid_2-s2.0-70350074490
- PMID: 19829373
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Article: Electrophysiology in the age of light
Title | Electrophysiology in the age of light |
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Authors | |
Issue Date | 2009 |
Citation | Nature, 2009, v. 461, n. 7266, p. 930-939 How to Cite? |
Abstract | Electrophysiology, the 'gold standard' for investigating neuronal signalling, is being challenged by a new generation of optical probes. Together with new forms of microscopy, these probes allow us to measure and control neuronal signals with spatial resolution and genetic specificity that already greatly surpass those of electrophysiology. We predict that the photon will progressively replace the electron for probing neuronal function, particularly for targeted stimulation and silencing of neuronal populations. Although electrophysiological characterization of channels, cells and neural circuits will remain necessary, new combinations of electrophysiology and imaging should lead to transformational discoveries in neuroscience. © 2009 Macmillan Publishers Limited. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/343053 |
ISSN | 2023 Impact Factor: 50.5 2023 SCImago Journal Rankings: 18.509 |
DC Field | Value | Language |
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dc.contributor.author | Scanziani, Massimo | - |
dc.contributor.author | Häusser, Michael | - |
dc.date.accessioned | 2024-05-10T09:05:04Z | - |
dc.date.available | 2024-05-10T09:05:04Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Nature, 2009, v. 461, n. 7266, p. 930-939 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343053 | - |
dc.description.abstract | Electrophysiology, the 'gold standard' for investigating neuronal signalling, is being challenged by a new generation of optical probes. Together with new forms of microscopy, these probes allow us to measure and control neuronal signals with spatial resolution and genetic specificity that already greatly surpass those of electrophysiology. We predict that the photon will progressively replace the electron for probing neuronal function, particularly for targeted stimulation and silencing of neuronal populations. Although electrophysiological characterization of channels, cells and neural circuits will remain necessary, new combinations of electrophysiology and imaging should lead to transformational discoveries in neuroscience. © 2009 Macmillan Publishers Limited. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature | - |
dc.title | Electrophysiology in the age of light | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/nature08540 | - |
dc.identifier.pmid | 19829373 | - |
dc.identifier.scopus | eid_2-s2.0-70350074490 | - |
dc.identifier.volume | 461 | - |
dc.identifier.issue | 7266 | - |
dc.identifier.spage | 930 | - |
dc.identifier.epage | 939 | - |
dc.identifier.eissn | 1476-4687 | - |