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- Publisher Website: 10.1016/j.fct.2010.04.039
- Scopus: eid_2-s2.0-77955048970
- PMID: 20438793
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Article: Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa
Title | Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa |
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Authors | |
Keywords | Apoptosis Breast cancer Immunomodulatory Peripheral blood mononuclear cells Turmerone |
Issue Date | 2010 |
Citation | Food and Chemical Toxicology, 2010, v. 48, n. 8-9, p. 2011-2020 How to Cite? |
Abstract | The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers. The present study evaluated the anti-proliferative activities of the isolated compounds (three curcuminoids and two turmerones) from CL, using human cancer cell lines HepG2, MCF-7 and MDA-MB-231. The immunomodulatory activities of turmerones (α and aromatic) isolated from CL were also examined using human peripheral blood mononuclear cells (PBMC). Our results showed that the curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) and α-turmerone significantly inhibited proliferation of cancer cells in dose-dependent manner. The IC50 values of these compounds in cancer cells ranged from 11.0 to 41.8μg/ml α-Turmerone induced MDA-MB-231 cells to undergo apoptosis, which was confirmed by annexin-V and propidium iodide staining, and DNA fragmentation assay. The caspase cascade was activated as shown by a significant decrease of procaspases-3, -8 and -9 in α-turmerone treated cells. Both α-turmerone and aromatic-turmerone showed stimulatory effects on PBMC proliferation and cytokine production. The anti-proliferative effect of α-turmerone and immunomodulatory activities of ar-turmerone was shown for the first time. The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent. © 2010 Elsevier Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/343056 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 0.780 |
DC Field | Value | Language |
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dc.contributor.author | Yue, Grace G.L. | - |
dc.contributor.author | Chan, Ben C.L. | - |
dc.contributor.author | Hon, Po Ming | - |
dc.contributor.author | Lee, Mavis Y.H. | - |
dc.contributor.author | Fung, Kwok Pui | - |
dc.contributor.author | Leung, Ping Chung | - |
dc.contributor.author | Lau, Clara B.S. | - |
dc.date.accessioned | 2024-05-10T09:05:06Z | - |
dc.date.available | 2024-05-10T09:05:06Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Food and Chemical Toxicology, 2010, v. 48, n. 8-9, p. 2011-2020 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343056 | - |
dc.description.abstract | The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers. The present study evaluated the anti-proliferative activities of the isolated compounds (three curcuminoids and two turmerones) from CL, using human cancer cell lines HepG2, MCF-7 and MDA-MB-231. The immunomodulatory activities of turmerones (α and aromatic) isolated from CL were also examined using human peripheral blood mononuclear cells (PBMC). Our results showed that the curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) and α-turmerone significantly inhibited proliferation of cancer cells in dose-dependent manner. The IC50 values of these compounds in cancer cells ranged from 11.0 to 41.8μg/ml α-Turmerone induced MDA-MB-231 cells to undergo apoptosis, which was confirmed by annexin-V and propidium iodide staining, and DNA fragmentation assay. The caspase cascade was activated as shown by a significant decrease of procaspases-3, -8 and -9 in α-turmerone treated cells. Both α-turmerone and aromatic-turmerone showed stimulatory effects on PBMC proliferation and cytokine production. The anti-proliferative effect of α-turmerone and immunomodulatory activities of ar-turmerone was shown for the first time. The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent. © 2010 Elsevier Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Food and Chemical Toxicology | - |
dc.subject | Apoptosis | - |
dc.subject | Breast cancer | - |
dc.subject | Immunomodulatory | - |
dc.subject | Peripheral blood mononuclear cells | - |
dc.subject | Turmerone | - |
dc.title | Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.fct.2010.04.039 | - |
dc.identifier.pmid | 20438793 | - |
dc.identifier.scopus | eid_2-s2.0-77955048970 | - |
dc.identifier.volume | 48 | - |
dc.identifier.issue | 8-9 | - |
dc.identifier.spage | 2011 | - |
dc.identifier.epage | 2020 | - |