File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/ptr.4743
- Scopus: eid_2-s2.0-84876295421
- PMID: 22628292
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action
Title | The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action |
---|---|
Authors | |
Keywords | adipogenesis disuse osteoporosis Epimedii Herba Ligustri Lucidi Fructus mesenchymal stem cell osteoclastogenesis osteogenesis Psoraleae Fructus tail-suspension |
Issue Date | 2013 |
Citation | Phytotherapy Research, 2013, v. 27, n. 4, p. 484-492 How to Cite? |
Abstract | An innovative anti-osteoporosis herbal formula containing Epimedii Herba, Ligustri Lucidi Fructus and Psoraleae Fructus (ELP) has been previously shown its bone protecting effects in ovariectomized osteoporotic rats and also in post-menopausal osteopenic women. This study aimed to investigate the efficacy of ELP against bone loss during physical inactivity or weightlessness. A hindlimb unloading tail-suspended rat model was used for studying the effects of ELP on bone mineral density (BMD) and bone micro-architecture. For in vitro mechanistic studies, rat mesenchymal stem cells (MSCs) and mouse macrophage cells (RAW264.7) were used for studying the effects of ELP on osteogenic/adipogenic differentiations and osteoclastogenesis, respectively. Our data illustrated that ELP had a significant preventive effect against bone loss induced by tail-suspension (TS) at day 28 (p < 0.01) as indicated in the reduction in BMD loss and the preservation of bone micro-architecture. ELP could significantly promote the osteogenesis and suppress the adipogenesis (p < 0.05) in MSCs. Besides, significant inhibition of osteoclast formation (p < 0.01) was found in ELP-treated RAW264.7 cells upon receptor activator of nuclear factor kappa-B ligand induction. Our study presents the first scientific evidence that ELP had a significant preventive effect against bone loss induced by TS through the actions of enhancing osteogenesis, suppressing adipogenesis and osteoclastogenesis. Copyright © 2012 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/343119 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 1.277 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Siu, Wing Sum | - |
dc.contributor.author | Wong, Hing Lok | - |
dc.contributor.author | Lau, Ching Po | - |
dc.contributor.author | Shum, Wai Ting | - |
dc.contributor.author | Wong, Chun Wai | - |
dc.contributor.author | Gao, Si | - |
dc.contributor.author | Fung, Kwok Pui | - |
dc.contributor.author | Lau, Clara Bik San | - |
dc.contributor.author | Hung, Leung Kim | - |
dc.contributor.author | Ko, Chun Hay | - |
dc.contributor.author | Leung, Ping Chung | - |
dc.date.accessioned | 2024-05-10T09:05:35Z | - |
dc.date.available | 2024-05-10T09:05:35Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Phytotherapy Research, 2013, v. 27, n. 4, p. 484-492 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | http://hdl.handle.net/10722/343119 | - |
dc.description.abstract | An innovative anti-osteoporosis herbal formula containing Epimedii Herba, Ligustri Lucidi Fructus and Psoraleae Fructus (ELP) has been previously shown its bone protecting effects in ovariectomized osteoporotic rats and also in post-menopausal osteopenic women. This study aimed to investigate the efficacy of ELP against bone loss during physical inactivity or weightlessness. A hindlimb unloading tail-suspended rat model was used for studying the effects of ELP on bone mineral density (BMD) and bone micro-architecture. For in vitro mechanistic studies, rat mesenchymal stem cells (MSCs) and mouse macrophage cells (RAW264.7) were used for studying the effects of ELP on osteogenic/adipogenic differentiations and osteoclastogenesis, respectively. Our data illustrated that ELP had a significant preventive effect against bone loss induced by tail-suspension (TS) at day 28 (p < 0.01) as indicated in the reduction in BMD loss and the preservation of bone micro-architecture. ELP could significantly promote the osteogenesis and suppress the adipogenesis (p < 0.05) in MSCs. Besides, significant inhibition of osteoclast formation (p < 0.01) was found in ELP-treated RAW264.7 cells upon receptor activator of nuclear factor kappa-B ligand induction. Our study presents the first scientific evidence that ELP had a significant preventive effect against bone loss induced by TS through the actions of enhancing osteogenesis, suppressing adipogenesis and osteoclastogenesis. Copyright © 2012 John Wiley & Sons, Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Phytotherapy Research | - |
dc.subject | adipogenesis | - |
dc.subject | disuse osteoporosis | - |
dc.subject | Epimedii Herba | - |
dc.subject | Ligustri Lucidi Fructus | - |
dc.subject | mesenchymal stem cell | - |
dc.subject | osteoclastogenesis | - |
dc.subject | osteogenesis | - |
dc.subject | Psoraleae Fructus | - |
dc.subject | tail-suspension | - |
dc.title | The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/ptr.4743 | - |
dc.identifier.pmid | 22628292 | - |
dc.identifier.scopus | eid_2-s2.0-84876295421 | - |
dc.identifier.volume | 27 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 484 | - |
dc.identifier.epage | 492 | - |
dc.identifier.eissn | 1099-1573 | - |