File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action

TitleThe effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action
Authors
Keywordsadipogenesis
disuse osteoporosis
Epimedii Herba
Ligustri Lucidi Fructus
mesenchymal stem cell
osteoclastogenesis
osteogenesis
Psoraleae Fructus
tail-suspension
Issue Date2013
Citation
Phytotherapy Research, 2013, v. 27, n. 4, p. 484-492 How to Cite?
AbstractAn innovative anti-osteoporosis herbal formula containing Epimedii Herba, Ligustri Lucidi Fructus and Psoraleae Fructus (ELP) has been previously shown its bone protecting effects in ovariectomized osteoporotic rats and also in post-menopausal osteopenic women. This study aimed to investigate the efficacy of ELP against bone loss during physical inactivity or weightlessness. A hindlimb unloading tail-suspended rat model was used for studying the effects of ELP on bone mineral density (BMD) and bone micro-architecture. For in vitro mechanistic studies, rat mesenchymal stem cells (MSCs) and mouse macrophage cells (RAW264.7) were used for studying the effects of ELP on osteogenic/adipogenic differentiations and osteoclastogenesis, respectively. Our data illustrated that ELP had a significant preventive effect against bone loss induced by tail-suspension (TS) at day 28 (p < 0.01) as indicated in the reduction in BMD loss and the preservation of bone micro-architecture. ELP could significantly promote the osteogenesis and suppress the adipogenesis (p < 0.05) in MSCs. Besides, significant inhibition of osteoclast formation (p < 0.01) was found in ELP-treated RAW264.7 cells upon receptor activator of nuclear factor kappa-B ligand induction. Our study presents the first scientific evidence that ELP had a significant preventive effect against bone loss induced by TS through the actions of enhancing osteogenesis, suppressing adipogenesis and osteoclastogenesis. Copyright © 2012 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/343119
ISSN
2021 Impact Factor: 6.388
2020 SCImago Journal Rankings: 1.019

 

DC FieldValueLanguage
dc.contributor.authorSiu, Wing Sum-
dc.contributor.authorWong, Hing Lok-
dc.contributor.authorLau, Ching Po-
dc.contributor.authorShum, Wai Ting-
dc.contributor.authorWong, Chun Wai-
dc.contributor.authorGao, Si-
dc.contributor.authorFung, Kwok Pui-
dc.contributor.authorLau, Clara Bik San-
dc.contributor.authorHung, Leung Kim-
dc.contributor.authorKo, Chun Hay-
dc.contributor.authorLeung, Ping Chung-
dc.date.accessioned2024-05-10T09:05:35Z-
dc.date.available2024-05-10T09:05:35Z-
dc.date.issued2013-
dc.identifier.citationPhytotherapy Research, 2013, v. 27, n. 4, p. 484-492-
dc.identifier.issn0951-418X-
dc.identifier.urihttp://hdl.handle.net/10722/343119-
dc.description.abstractAn innovative anti-osteoporosis herbal formula containing Epimedii Herba, Ligustri Lucidi Fructus and Psoraleae Fructus (ELP) has been previously shown its bone protecting effects in ovariectomized osteoporotic rats and also in post-menopausal osteopenic women. This study aimed to investigate the efficacy of ELP against bone loss during physical inactivity or weightlessness. A hindlimb unloading tail-suspended rat model was used for studying the effects of ELP on bone mineral density (BMD) and bone micro-architecture. For in vitro mechanistic studies, rat mesenchymal stem cells (MSCs) and mouse macrophage cells (RAW264.7) were used for studying the effects of ELP on osteogenic/adipogenic differentiations and osteoclastogenesis, respectively. Our data illustrated that ELP had a significant preventive effect against bone loss induced by tail-suspension (TS) at day 28 (p < 0.01) as indicated in the reduction in BMD loss and the preservation of bone micro-architecture. ELP could significantly promote the osteogenesis and suppress the adipogenesis (p < 0.05) in MSCs. Besides, significant inhibition of osteoclast formation (p < 0.01) was found in ELP-treated RAW264.7 cells upon receptor activator of nuclear factor kappa-B ligand induction. Our study presents the first scientific evidence that ELP had a significant preventive effect against bone loss induced by TS through the actions of enhancing osteogenesis, suppressing adipogenesis and osteoclastogenesis. Copyright © 2012 John Wiley & Sons, Ltd.-
dc.languageeng-
dc.relation.ispartofPhytotherapy Research-
dc.subjectadipogenesis-
dc.subjectdisuse osteoporosis-
dc.subjectEpimedii Herba-
dc.subjectLigustri Lucidi Fructus-
dc.subjectmesenchymal stem cell-
dc.subjectosteoclastogenesis-
dc.subjectosteogenesis-
dc.subjectPsoraleae Fructus-
dc.subjecttail-suspension-
dc.titleThe effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ptr.4743-
dc.identifier.pmid22628292-
dc.identifier.scopuseid_2-s2.0-84876295421-
dc.identifier.volume27-
dc.identifier.issue4-
dc.identifier.spage484-
dc.identifier.epage492-
dc.identifier.eissn1099-1573-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats