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Article: Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin - The importance of turmerones

TitleTurmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin - The importance of turmerones
Authors
KeywordsAngiogenesis
Colorectal cancer
Curcuma longa
Curcumin
Synergism
Turmerone
Issue Date2016
Citation
Journal of Functional Foods, 2016, v. 22, p. 565-577 How to Cite?
AbstractThe active ingredient curcuminoid (including curcumin, demethoxycurcumin and bisdemethoxycurcumin) from the Asian medicinal and culinary herb turmeric possesses anti-tumour effects, but poor oral absorption in the intestine impedes its widespread clinical application. Our previous study showed that turmerones increased the accumulation of curcumin inside colonic cells. The present study demonstrates the enhanced anti-proliferative and anti-angiogenic activities of curcumin in the presence of turmerones in human colon cancer cells and endothelial cells, respectively. Furthermore, in HT29 tumour xenograft-bearing mice fed with curcumin alone or turmeric ethanolic extract (in which the concentration of curcumin was kept the same), the tumour burden of turmeric extract-fed mice was the lowest, suggesting turmeric extract provided better anti-tumour activities than the same amount of curcumin alone did. The superior anti-tumour effects of turmeric extract, which contains curcumin, turmerones and other constituents, were verified in tumour-bearing mice, indicating the potential use of turmeric for colorectal cancer adjuvant therapy.
Persistent Identifierhttp://hdl.handle.net/10722/343202
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.900

 

DC FieldValueLanguage
dc.contributor.authorYue, Grace Gar Lee-
dc.contributor.authorJiang, Lei-
dc.contributor.authorKwok, Hin Fai-
dc.contributor.authorLee, Julia Kin Ming-
dc.contributor.authorChan, Kar Man-
dc.contributor.authorFung, Kwok Pui-
dc.contributor.authorLeung, Ping Chung-
dc.contributor.authorLau, Clara Bik San-
dc.date.accessioned2024-05-10T09:06:15Z-
dc.date.available2024-05-10T09:06:15Z-
dc.date.issued2016-
dc.identifier.citationJournal of Functional Foods, 2016, v. 22, p. 565-577-
dc.identifier.issn1756-4646-
dc.identifier.urihttp://hdl.handle.net/10722/343202-
dc.description.abstractThe active ingredient curcuminoid (including curcumin, demethoxycurcumin and bisdemethoxycurcumin) from the Asian medicinal and culinary herb turmeric possesses anti-tumour effects, but poor oral absorption in the intestine impedes its widespread clinical application. Our previous study showed that turmerones increased the accumulation of curcumin inside colonic cells. The present study demonstrates the enhanced anti-proliferative and anti-angiogenic activities of curcumin in the presence of turmerones in human colon cancer cells and endothelial cells, respectively. Furthermore, in HT29 tumour xenograft-bearing mice fed with curcumin alone or turmeric ethanolic extract (in which the concentration of curcumin was kept the same), the tumour burden of turmeric extract-fed mice was the lowest, suggesting turmeric extract provided better anti-tumour activities than the same amount of curcumin alone did. The superior anti-tumour effects of turmeric extract, which contains curcumin, turmerones and other constituents, were verified in tumour-bearing mice, indicating the potential use of turmeric for colorectal cancer adjuvant therapy.-
dc.languageeng-
dc.relation.ispartofJournal of Functional Foods-
dc.subjectAngiogenesis-
dc.subjectColorectal cancer-
dc.subjectCurcuma longa-
dc.subjectCurcumin-
dc.subjectSynergism-
dc.subjectTurmerone-
dc.titleTurmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin - The importance of turmerones-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jff.2016.02.011-
dc.identifier.scopuseid_2-s2.0-84958818529-
dc.identifier.volume22-
dc.identifier.spage565-
dc.identifier.epage577-

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