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- Publisher Website: 10.1016/j.jff.2016.02.011
- Scopus: eid_2-s2.0-84958818529
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Article: Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin - The importance of turmerones
Title | Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin - The importance of turmerones |
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Authors | |
Keywords | Angiogenesis Colorectal cancer Curcuma longa Curcumin Synergism Turmerone |
Issue Date | 2016 |
Citation | Journal of Functional Foods, 2016, v. 22, p. 565-577 How to Cite? |
Abstract | The active ingredient curcuminoid (including curcumin, demethoxycurcumin and bisdemethoxycurcumin) from the Asian medicinal and culinary herb turmeric possesses anti-tumour effects, but poor oral absorption in the intestine impedes its widespread clinical application. Our previous study showed that turmerones increased the accumulation of curcumin inside colonic cells. The present study demonstrates the enhanced anti-proliferative and anti-angiogenic activities of curcumin in the presence of turmerones in human colon cancer cells and endothelial cells, respectively. Furthermore, in HT29 tumour xenograft-bearing mice fed with curcumin alone or turmeric ethanolic extract (in which the concentration of curcumin was kept the same), the tumour burden of turmeric extract-fed mice was the lowest, suggesting turmeric extract provided better anti-tumour activities than the same amount of curcumin alone did. The superior anti-tumour effects of turmeric extract, which contains curcumin, turmerones and other constituents, were verified in tumour-bearing mice, indicating the potential use of turmeric for colorectal cancer adjuvant therapy. |
Persistent Identifier | http://hdl.handle.net/10722/343202 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.900 |
DC Field | Value | Language |
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dc.contributor.author | Yue, Grace Gar Lee | - |
dc.contributor.author | Jiang, Lei | - |
dc.contributor.author | Kwok, Hin Fai | - |
dc.contributor.author | Lee, Julia Kin Ming | - |
dc.contributor.author | Chan, Kar Man | - |
dc.contributor.author | Fung, Kwok Pui | - |
dc.contributor.author | Leung, Ping Chung | - |
dc.contributor.author | Lau, Clara Bik San | - |
dc.date.accessioned | 2024-05-10T09:06:15Z | - |
dc.date.available | 2024-05-10T09:06:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of Functional Foods, 2016, v. 22, p. 565-577 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343202 | - |
dc.description.abstract | The active ingredient curcuminoid (including curcumin, demethoxycurcumin and bisdemethoxycurcumin) from the Asian medicinal and culinary herb turmeric possesses anti-tumour effects, but poor oral absorption in the intestine impedes its widespread clinical application. Our previous study showed that turmerones increased the accumulation of curcumin inside colonic cells. The present study demonstrates the enhanced anti-proliferative and anti-angiogenic activities of curcumin in the presence of turmerones in human colon cancer cells and endothelial cells, respectively. Furthermore, in HT29 tumour xenograft-bearing mice fed with curcumin alone or turmeric ethanolic extract (in which the concentration of curcumin was kept the same), the tumour burden of turmeric extract-fed mice was the lowest, suggesting turmeric extract provided better anti-tumour activities than the same amount of curcumin alone did. The superior anti-tumour effects of turmeric extract, which contains curcumin, turmerones and other constituents, were verified in tumour-bearing mice, indicating the potential use of turmeric for colorectal cancer adjuvant therapy. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Functional Foods | - |
dc.subject | Angiogenesis | - |
dc.subject | Colorectal cancer | - |
dc.subject | Curcuma longa | - |
dc.subject | Curcumin | - |
dc.subject | Synergism | - |
dc.subject | Turmerone | - |
dc.title | Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin - The importance of turmerones | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jff.2016.02.011 | - |
dc.identifier.scopus | eid_2-s2.0-84958818529 | - |
dc.identifier.volume | 22 | - |
dc.identifier.spage | 565 | - |
dc.identifier.epage | 577 | - |