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Article: Multitargeted combination effects of a triherbal formulation containing ELP against osteoporosis: In vitro evidence

TitleMultitargeted combination effects of a triherbal formulation containing ELP against osteoporosis: In vitro evidence
Authors
Keywordsanti-osteoporotic herbal formula
combination effects
Epimedii Herba
Ligustri Lucidi Fructus
Psoraleae Fructus
synergy
Issue Date2016
Citation
Journal of Pharmacy and Pharmacology, 2016, v. 68, n. 6, p. 826-833 How to Cite?
AbstractObjectives An anti-osteoporotic herbal formula ELP containing Epimedii Herba (E), Ligustri Lucidi Fructus (L) and Psoraleae Fructus (P) was studied to investigate the herb-herb interaction (or the possible synergistic effect) among each component and to identify the principal herbs in different modes of action. Methods Rat osteoblast-like UMR-106 cells proliferation, rat MSCs-derived osteoblastogenesis and RANKL-induced RAW 264.7 osteoclastogenesis were adopted to investigate the bone-forming activity and bone-degrading activity of the herbal extracts. In the statistical aspect, a modified Tallarida's approach was employed to assess the synergistic effects in herbal combinations. Key findings Psoraleae Fructus is the active herb for stimulating osteoblast proliferation, and mild synergy was detected in the pairwise combinations EL, LP and formula ELP. In osteoblastogenesis assay, E and L are the principal herbs for promoting osteoblast differentiation and significant synergy was detected in the pairwise combination EL. For inhibiting osteoclast formation, L is the active herb and significant synergy was detected in the 3-way combination ELP. Conclusions The presence of E, L and P is essential for ELP formula as a whole to act against osteoporosis via enhancing bone formation and reducing bone reabsorption. An optimal dosage at 150 μg/ml was proposed for ELP based on our findings.
Persistent Identifierhttp://hdl.handle.net/10722/343207
ISSN
2023 Impact Factor: 2.8
2023 SCImago Journal Rankings: 0.648

 

DC FieldValueLanguage
dc.contributor.authorKo, Chun Hay-
dc.contributor.authorLau, Kit Man-
dc.contributor.authorChau, Lily-
dc.contributor.authorCheung, David Wing Shing-
dc.contributor.authorSiu, Wing Sum-
dc.contributor.authorWong, Hing Lok-
dc.contributor.authorShum, Wai Ting-
dc.contributor.authorGao, Si-
dc.contributor.authorFung, Kwok Pui-
dc.contributor.authorLeung, Ping Chung-
dc.contributor.authorPoon, Simon Kar Sing-
dc.contributor.authorLau, Clara Bik San-
dc.date.accessioned2024-05-10T09:06:18Z-
dc.date.available2024-05-10T09:06:18Z-
dc.date.issued2016-
dc.identifier.citationJournal of Pharmacy and Pharmacology, 2016, v. 68, n. 6, p. 826-833-
dc.identifier.issn0022-3573-
dc.identifier.urihttp://hdl.handle.net/10722/343207-
dc.description.abstractObjectives An anti-osteoporotic herbal formula ELP containing Epimedii Herba (E), Ligustri Lucidi Fructus (L) and Psoraleae Fructus (P) was studied to investigate the herb-herb interaction (or the possible synergistic effect) among each component and to identify the principal herbs in different modes of action. Methods Rat osteoblast-like UMR-106 cells proliferation, rat MSCs-derived osteoblastogenesis and RANKL-induced RAW 264.7 osteoclastogenesis were adopted to investigate the bone-forming activity and bone-degrading activity of the herbal extracts. In the statistical aspect, a modified Tallarida's approach was employed to assess the synergistic effects in herbal combinations. Key findings Psoraleae Fructus is the active herb for stimulating osteoblast proliferation, and mild synergy was detected in the pairwise combinations EL, LP and formula ELP. In osteoblastogenesis assay, E and L are the principal herbs for promoting osteoblast differentiation and significant synergy was detected in the pairwise combination EL. For inhibiting osteoclast formation, L is the active herb and significant synergy was detected in the 3-way combination ELP. Conclusions The presence of E, L and P is essential for ELP formula as a whole to act against osteoporosis via enhancing bone formation and reducing bone reabsorption. An optimal dosage at 150 μg/ml was proposed for ELP based on our findings.-
dc.languageeng-
dc.relation.ispartofJournal of Pharmacy and Pharmacology-
dc.subjectanti-osteoporotic herbal formula-
dc.subjectcombination effects-
dc.subjectEpimedii Herba-
dc.subjectLigustri Lucidi Fructus-
dc.subjectPsoraleae Fructus-
dc.subjectsynergy-
dc.titleMultitargeted combination effects of a triherbal formulation containing ELP against osteoporosis: In vitro evidence-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jphp.12542-
dc.identifier.pmid27019348-
dc.identifier.scopuseid_2-s2.0-84962164184-
dc.identifier.volume68-
dc.identifier.issue6-
dc.identifier.spage826-
dc.identifier.epage833-
dc.identifier.eissn2042-7158-

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