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- Publisher Website: 10.1007/s11655-014-1625-1
- Scopus: eid_2-s2.0-84975864610
- PMID: 25159862
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Article: Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model
Title | Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model |
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Authors | |
Keywords | Anemarrhena asphodeloides caffeine Chinese medicine hypnotic effects Polygala tenuifolia Polygonum multiflorum Poria cocos Triticum aestivu Ziziphus jujube |
Issue Date | 2016 |
Citation | Chinese Journal of Integrative Medicine, 2016, v. 22, n. 5, p. 335-343 How to Cite? |
Abstract | Objective: To assess the biological effects of the six-herb mixture Anti-Insomia Formula (AIF) extract using caffeine-induced insomnia Drosophila model and short-sleep mutants. Methods: Caffeineinduced insomnia wild-type Drosophila and short-sleep mutant flies minisleep (mns) and HyperkineticY (HkY) were used to assess the hypnotic effects of the AIF in vivo. The night time activity, the amount of night time sleep and the number of sleep bouts were determined using Drosophila activity monitoring system. Sleep was defined as any period of uninterrupted behavioral immobility (0 count per minute) lasting > 5 min. Night time sleep was calculated by summing up the sleep time in the dark period. Number of sleep bouts was calculated by counting the number of sleep episodes in the dark period. Results: AIF at the dosage of 50 mg/mL, effectively attenuated caffeine-induced wakefulness (P<0.01) in wild-type Canton-S flies as indicated by the reduction of the sleep bouts, night time activities and increase of the amount of night time sleep. AIF also significantly reduced sleeping time of short-sleep HkY mutant flies (P<0.01). However, AIF did not produce similar effect in mns mutants. Conclusion: AIF might be able to rescue the abnormal condition caused by mutated modulatory subunit of the tetrameric potassium channel, but not rescuing the abnormal nerve firing caused by Shaker gene mutation. This study provides the scientific evidence to support the use of AIF in Chinese medicine for promoting sleep quality in insomnia. |
Persistent Identifier | http://hdl.handle.net/10722/343218 |
ISSN | 2023 Impact Factor: 2.2 2023 SCImago Journal Rankings: 0.502 |
DC Field | Value | Language |
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dc.contributor.author | Ko, Chun hay | - |
dc.contributor.author | Koon, Chi man | - |
dc.contributor.author | Yu, Siu lung | - |
dc.contributor.author | Lee, Kwok ying | - |
dc.contributor.author | Lau, Clara Bik san | - |
dc.contributor.author | Chan, Edwin Ho yin | - |
dc.contributor.author | Wing, Yun kwok | - |
dc.contributor.author | Fung, Kwok pui | - |
dc.contributor.author | Leung, Ping chung | - |
dc.date.accessioned | 2024-05-10T09:06:23Z | - |
dc.date.available | 2024-05-10T09:06:23Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Chinese Journal of Integrative Medicine, 2016, v. 22, n. 5, p. 335-343 | - |
dc.identifier.issn | 1672-0415 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343218 | - |
dc.description.abstract | Objective: To assess the biological effects of the six-herb mixture Anti-Insomia Formula (AIF) extract using caffeine-induced insomnia Drosophila model and short-sleep mutants. Methods: Caffeineinduced insomnia wild-type Drosophila and short-sleep mutant flies minisleep (mns) and HyperkineticY (HkY) were used to assess the hypnotic effects of the AIF in vivo. The night time activity, the amount of night time sleep and the number of sleep bouts were determined using Drosophila activity monitoring system. Sleep was defined as any period of uninterrupted behavioral immobility (0 count per minute) lasting > 5 min. Night time sleep was calculated by summing up the sleep time in the dark period. Number of sleep bouts was calculated by counting the number of sleep episodes in the dark period. Results: AIF at the dosage of 50 mg/mL, effectively attenuated caffeine-induced wakefulness (P<0.01) in wild-type Canton-S flies as indicated by the reduction of the sleep bouts, night time activities and increase of the amount of night time sleep. AIF also significantly reduced sleeping time of short-sleep HkY mutant flies (P<0.01). However, AIF did not produce similar effect in mns mutants. Conclusion: AIF might be able to rescue the abnormal condition caused by mutated modulatory subunit of the tetrameric potassium channel, but not rescuing the abnormal nerve firing caused by Shaker gene mutation. This study provides the scientific evidence to support the use of AIF in Chinese medicine for promoting sleep quality in insomnia. | - |
dc.language | eng | - |
dc.relation.ispartof | Chinese Journal of Integrative Medicine | - |
dc.subject | Anemarrhena asphodeloides | - |
dc.subject | caffeine | - |
dc.subject | Chinese medicine | - |
dc.subject | hypnotic effects | - |
dc.subject | Polygala tenuifolia | - |
dc.subject | Polygonum multiflorum | - |
dc.subject | Poria cocos | - |
dc.subject | Triticum aestivu | - |
dc.subject | Ziziphus jujube | - |
dc.title | Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s11655-014-1625-1 | - |
dc.identifier.pmid | 25159862 | - |
dc.identifier.scopus | eid_2-s2.0-84975864610 | - |
dc.identifier.volume | 22 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 335 | - |
dc.identifier.epage | 343 | - |
dc.identifier.eissn | 1993-0402 | - |