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Article: Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi

TitleMelodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi
Authors
KeywordsBisindole
Cell cycle arrest
Cellular apoptosis
HT-29 cells
Inhibited cell proliferation
Melodinine V
Issue Date2016
Citation
Bioorganic and Medicinal Chemistry Letters, 2016, v. 26, n. 20, p. 4895-4898 How to Cite?
AbstractMelodinine V (1) with a vincanol–eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells.
Persistent Identifierhttp://hdl.handle.net/10722/343225
ISSN
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.508

 

DC FieldValueLanguage
dc.contributor.authorLiu, Ya Ping-
dc.contributor.authorYue, Grace Gar Lee-
dc.contributor.authorLee, Julia Kin Ming-
dc.contributor.authorFeng, Tao-
dc.contributor.authorZhao, Yun Li-
dc.contributor.authorLi, Yan-
dc.contributor.authorLau, Clara Bik San-
dc.contributor.authorLuo, Xiao Dong-
dc.date.accessioned2024-05-10T09:06:26Z-
dc.date.available2024-05-10T09:06:26Z-
dc.date.issued2016-
dc.identifier.citationBioorganic and Medicinal Chemistry Letters, 2016, v. 26, n. 20, p. 4895-4898-
dc.identifier.issn0960-894X-
dc.identifier.urihttp://hdl.handle.net/10722/343225-
dc.description.abstractMelodinine V (1) with a vincanol–eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells.-
dc.languageeng-
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters-
dc.subjectBisindole-
dc.subjectCell cycle arrest-
dc.subjectCellular apoptosis-
dc.subjectHT-29 cells-
dc.subjectInhibited cell proliferation-
dc.subjectMelodinine V-
dc.titleMelodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bmcl.2016.09.023-
dc.identifier.pmid27650926-
dc.identifier.scopuseid_2-s2.0-84989211371-
dc.identifier.volume26-
dc.identifier.issue20-
dc.identifier.spage4895-
dc.identifier.epage4898-
dc.identifier.eissn1464-3405-

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