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- Publisher Website: 10.3892/etm.2017.4053
- Scopus: eid_2-s2.0-85011599004
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Article: Whole extracts of radix achyranthis bidentatae and radix cyathulae promote angiogenesis in human umbilical vein endothelial cells in vitro and in zebrafish in vivo
Title | Whole extracts of radix achyranthis bidentatae and radix cyathulae promote angiogenesis in human umbilical vein endothelial cells in vitro and in zebrafish in vivo |
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Authors | |
Keywords | Cell migration Pro-angiogenesis Radix achyranthis bidentatae Radix cyathulae Zebrafish |
Issue Date | 2017 |
Citation | Experimental and Therapeutic Medicine, 2017, v. 13, n. 3, p. 1032-1038 How to Cite? |
Abstract | Although Radix Achyranthis Bidentatae (RAB) and Radix Cyathulae (RC) are from two different medicinal plants, they are both used as ‘Niu-Xi’, a widely used traditional Chinese medicine that is believed to stimulate menstruation and affect bone injury. Angiogenesis is actively involved in treating these illnesses. The aim of the present study was to investigate whether the whole extracts of RAB and RC possess pro-angiogenic effects. In order to examine this idea whole extracts of RAB and RC were extracted with boiling water followed by ethanol, respectively. Results from the MTT, wound healing and tube formation assays in human umbilical vein endothelial cells (HUVECs) in vitro revealed that the whole extracts of RAB and RC did not increase cell proliferation or tube formation, but enhanced cell migration. Their angiogenic effects were also confirmed in zebrafish in vivo via increasing the sprout numbers in the sub-intestinal vessel. As determined by quantitative polymerase chain reaction, the whole extracts of RAB and RC both regulated the expression of cell migration-related genes in zebrafish. It is concluded that the whole extracts of RAB and RC induced angiogenesis in HUVECs in vitro and in zebrafish in vivo via increasing cell migration. |
Persistent Identifier | http://hdl.handle.net/10722/343234 |
ISSN | 2023 Impact Factor: 2.4 2019 SCImago Journal Rankings: 0.508 |
DC Field | Value | Language |
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dc.contributor.author | Zhou, Xuelin | - |
dc.contributor.author | Siu, Wing Sum | - |
dc.contributor.author | Zhang, Cheng | - |
dc.contributor.author | Liu, Cheuk Lun | - |
dc.contributor.author | Cheng, Ling | - |
dc.contributor.author | Kwok, Hin Fai | - |
dc.contributor.author | Fung, Chak Hei | - |
dc.contributor.author | Tam, Jacqueline Chor Wing | - |
dc.contributor.author | Lau, Ching Po | - |
dc.contributor.author | Lau, Clara Bik San | - |
dc.contributor.author | Leung, Ping Chung | - |
dc.contributor.author | Hung, Leung Kim | - |
dc.contributor.author | Ko, Chun Hay | - |
dc.date.accessioned | 2024-05-10T09:06:30Z | - |
dc.date.available | 2024-05-10T09:06:30Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Experimental and Therapeutic Medicine, 2017, v. 13, n. 3, p. 1032-1038 | - |
dc.identifier.issn | 1792-0981 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343234 | - |
dc.description.abstract | Although Radix Achyranthis Bidentatae (RAB) and Radix Cyathulae (RC) are from two different medicinal plants, they are both used as ‘Niu-Xi’, a widely used traditional Chinese medicine that is believed to stimulate menstruation and affect bone injury. Angiogenesis is actively involved in treating these illnesses. The aim of the present study was to investigate whether the whole extracts of RAB and RC possess pro-angiogenic effects. In order to examine this idea whole extracts of RAB and RC were extracted with boiling water followed by ethanol, respectively. Results from the MTT, wound healing and tube formation assays in human umbilical vein endothelial cells (HUVECs) in vitro revealed that the whole extracts of RAB and RC did not increase cell proliferation or tube formation, but enhanced cell migration. Their angiogenic effects were also confirmed in zebrafish in vivo via increasing the sprout numbers in the sub-intestinal vessel. As determined by quantitative polymerase chain reaction, the whole extracts of RAB and RC both regulated the expression of cell migration-related genes in zebrafish. It is concluded that the whole extracts of RAB and RC induced angiogenesis in HUVECs in vitro and in zebrafish in vivo via increasing cell migration. | - |
dc.language | eng | - |
dc.relation.ispartof | Experimental and Therapeutic Medicine | - |
dc.subject | Cell migration | - |
dc.subject | Pro-angiogenesis | - |
dc.subject | Radix achyranthis bidentatae | - |
dc.subject | Radix cyathulae | - |
dc.subject | Zebrafish | - |
dc.title | Whole extracts of radix achyranthis bidentatae and radix cyathulae promote angiogenesis in human umbilical vein endothelial cells in vitro and in zebrafish in vivo | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.3892/etm.2017.4053 | - |
dc.identifier.scopus | eid_2-s2.0-85011599004 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 1032 | - |
dc.identifier.epage | 1038 | - |
dc.identifier.eissn | 1792-1015 | - |