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- Publisher Website: 10.7554/eLife.49872
- Scopus: eid_2-s2.0-85074738446
- PMID: 31657720
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Article: Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies
Title | Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies |
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Authors | |
Issue Date | 2019 |
Citation | eLife, 2019, v. 8, article no. e49872 How to Cite? |
Abstract | Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment, action potential initiation and repolarization, and rapid synchronous GABA release by PV+ cells is well established. In contrast, the functional significance of PV+ cell NMDA receptors (NMDARs), which generate relatively slow postsynaptic currents, is unclear. Underlining their importance, several studies implicate PV+ cell NMDAR disruption in impaired network function and circuit pathologies. Here, we show that dendritic NMDARs underlie supralinear integration of feedback excitation from local pyramidal neurons onto mouse CA1 PV+ cells. Furthermore, by incorporating NMDARs at feedback connections onto PV+ cells in spiking networks, we show that these receptors enable cooperative recruitment of PV+ interneurons, strengthening and stabilising principal cell assemblies. Failure of this phenomenon provides a parsimonious explanation for cognitive and sensory gating deficits in pathologies with impaired PV+ NMDAR signalling. |
Persistent Identifier | http://hdl.handle.net/10722/343290 |
DC Field | Value | Language |
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dc.contributor.author | Cornford, Jonathan | - |
dc.contributor.author | Mercier, Marion S. | - |
dc.contributor.author | Leite, Marco | - |
dc.contributor.author | Magloire, Vincent | - |
dc.contributor.author | Häusser, Michael | - |
dc.contributor.author | Kullmann, Dimitri M. | - |
dc.date.accessioned | 2024-05-10T09:06:57Z | - |
dc.date.available | 2024-05-10T09:06:57Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | eLife, 2019, v. 8, article no. e49872 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343290 | - |
dc.description.abstract | Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment, action potential initiation and repolarization, and rapid synchronous GABA release by PV+ cells is well established. In contrast, the functional significance of PV+ cell NMDA receptors (NMDARs), which generate relatively slow postsynaptic currents, is unclear. Underlining their importance, several studies implicate PV+ cell NMDAR disruption in impaired network function and circuit pathologies. Here, we show that dendritic NMDARs underlie supralinear integration of feedback excitation from local pyramidal neurons onto mouse CA1 PV+ cells. Furthermore, by incorporating NMDARs at feedback connections onto PV+ cells in spiking networks, we show that these receptors enable cooperative recruitment of PV+ interneurons, strengthening and stabilising principal cell assemblies. Failure of this phenomenon provides a parsimonious explanation for cognitive and sensory gating deficits in pathologies with impaired PV+ NMDAR signalling. | - |
dc.language | eng | - |
dc.relation.ispartof | eLife | - |
dc.title | Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.7554/eLife.49872 | - |
dc.identifier.pmid | 31657720 | - |
dc.identifier.scopus | eid_2-s2.0-85074738446 | - |
dc.identifier.volume | 8 | - |
dc.identifier.spage | article no. e49872 | - |
dc.identifier.epage | article no. e49872 | - |
dc.identifier.eissn | 2050-084X | - |