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Article: Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus

TitleImmunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus
Authors
Keywordscytotoxicity
heteronone
labdane diterpenoids
leojapone
Leonurus japonicus
lewis lung cancer
Issue Date2020
Citation
Journal of Pharmacy and Pharmacology, 2020, v. 72, n. 11, p. 1657-1665 How to Cite?
AbstractObjectives: Two labdane diterpenoids, leojapone B and heteronone B, were isolated from Leonurus japonicus Houtt., and their biological activity were evaluated in this study. Methods: Human and mouse cancer cells, human peripheral blood mononuclear cells (PBMCs) and mouse macrophages (RAW264.7 cells) were used to evaluate the activity of leojapone B and heteronone B, while the in vivo effects of leojapone B were further examined in Lewis Lung Cancer tumour-bearing mice. Key findings: In vitro studies showed that leojapone B selectively inhibited the proliferation of lung cancer cells, and both leojapone B and heteronone B inhibited the production of pro-inflammatory cytokines in activated PBMCs. In tumour-bearing mice model, lung tumours were reduced in size in mice treated with intraperitoneal injections of leojapone B at 20 and 30 mg/kg for 14 days. The population ratio of CD4+/CD8+ T cells in mouse spleens was found to be increased, while regulatory T cells were decreased after leojapone B treatment. Conclusions: The inhibitory effects of leojapone B in mouse lung tumours were demonstrated for the first time in this study. The immunomodulatory activity of heteronone B were also demonstrated. Our findings indicated that both leojapone B and heteronone B may act as active components in L. japonicus.
Persistent Identifierhttp://hdl.handle.net/10722/343311
ISSN
2023 Impact Factor: 2.8
2023 SCImago Journal Rankings: 0.648

 

DC FieldValueLanguage
dc.contributor.authorYue, Grace Gar Lee-
dc.contributor.authorLiang, Xin Xin-
dc.contributor.authorLi, Xiao Li-
dc.contributor.authorLee, Julia Kin Ming-
dc.contributor.authorGao, Si-
dc.contributor.authorKwok, Hin Fai-
dc.contributor.authorLau, Clara Bik San-
dc.contributor.authorXiao, Wei Lie-
dc.date.accessioned2024-05-10T09:07:06Z-
dc.date.available2024-05-10T09:07:06Z-
dc.date.issued2020-
dc.identifier.citationJournal of Pharmacy and Pharmacology, 2020, v. 72, n. 11, p. 1657-1665-
dc.identifier.issn0022-3573-
dc.identifier.urihttp://hdl.handle.net/10722/343311-
dc.description.abstractObjectives: Two labdane diterpenoids, leojapone B and heteronone B, were isolated from Leonurus japonicus Houtt., and their biological activity were evaluated in this study. Methods: Human and mouse cancer cells, human peripheral blood mononuclear cells (PBMCs) and mouse macrophages (RAW264.7 cells) were used to evaluate the activity of leojapone B and heteronone B, while the in vivo effects of leojapone B were further examined in Lewis Lung Cancer tumour-bearing mice. Key findings: In vitro studies showed that leojapone B selectively inhibited the proliferation of lung cancer cells, and both leojapone B and heteronone B inhibited the production of pro-inflammatory cytokines in activated PBMCs. In tumour-bearing mice model, lung tumours were reduced in size in mice treated with intraperitoneal injections of leojapone B at 20 and 30 mg/kg for 14 days. The population ratio of CD4+/CD8+ T cells in mouse spleens was found to be increased, while regulatory T cells were decreased after leojapone B treatment. Conclusions: The inhibitory effects of leojapone B in mouse lung tumours were demonstrated for the first time in this study. The immunomodulatory activity of heteronone B were also demonstrated. Our findings indicated that both leojapone B and heteronone B may act as active components in L. japonicus.-
dc.languageeng-
dc.relation.ispartofJournal of Pharmacy and Pharmacology-
dc.subjectcytotoxicity-
dc.subjectheteronone-
dc.subjectlabdane diterpenoids-
dc.subjectleojapone-
dc.subjectLeonurus japonicus-
dc.subjectlewis lung cancer-
dc.titleImmunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jphp.13348-
dc.identifier.pmid32757490-
dc.identifier.scopuseid_2-s2.0-85088989272-
dc.identifier.volume72-
dc.identifier.issue11-
dc.identifier.spage1657-
dc.identifier.epage1665-
dc.identifier.eissn2042-7158-

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