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Article: Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica
Title | Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica |
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Authors | |
Issue Date | 2022 |
Citation | New Journal of Chemistry, 2022, v. 47, n. 1, p. 324-332 How to Cite? |
Abstract | Phytochemical investigation on the whole plant of Ypsilandra thibetica led to the isolation of five new cholestane derivatives. The structures of 1-5 were elucidated by comprehensive spectroscopic analyses of their data and chemical methods. The absolute configurations of compounds 1-3 were ambiguously assigned by single crystal X-ray diffraction analysis. Compound 1 is the first cholestane glycoside with two oxygen bridges between C-16/C-23 and C-18/C-23. Compound 2 is the first 23-spirocholestane derivative with a six-membered ring between C-24/C-23 of the aglycone moiety and C-1′/C-2′ of the d-arabinose ligand, while compounds 3-5 are new 23-spirocholestane derivatives with a d-fucose ligand. The cytotoxic, anti-inflammatory, and anti-angiogenic activities of these isolated compounds were evaluated. Compound 5 showed anti-angiogenic activity in zebrafish embryos. |
Persistent Identifier | http://hdl.handle.net/10722/343398 |
ISSN | 2021 Impact Factor: 3.925 2020 SCImago Journal Rankings: 0.693 |
DC Field | Value | Language |
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dc.contributor.author | Xie, Jing | - |
dc.contributor.author | Zhang, Shi Juan | - |
dc.contributor.author | Yue, Grace Gar Lee | - |
dc.contributor.author | Yu, Ling Ling | - |
dc.contributor.author | Liu, Hui | - |
dc.contributor.author | Ma, Wen Yi | - |
dc.contributor.author | Yan, Huan | - |
dc.contributor.author | Ni, Wei | - |
dc.contributor.author | Lau, Clara Bik San | - |
dc.contributor.author | Liu, Hai Yang | - |
dc.date.accessioned | 2024-05-10T09:07:46Z | - |
dc.date.available | 2024-05-10T09:07:46Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | New Journal of Chemistry, 2022, v. 47, n. 1, p. 324-332 | - |
dc.identifier.issn | 1144-0546 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343398 | - |
dc.description.abstract | Phytochemical investigation on the whole plant of Ypsilandra thibetica led to the isolation of five new cholestane derivatives. The structures of 1-5 were elucidated by comprehensive spectroscopic analyses of their data and chemical methods. The absolute configurations of compounds 1-3 were ambiguously assigned by single crystal X-ray diffraction analysis. Compound 1 is the first cholestane glycoside with two oxygen bridges between C-16/C-23 and C-18/C-23. Compound 2 is the first 23-spirocholestane derivative with a six-membered ring between C-24/C-23 of the aglycone moiety and C-1′/C-2′ of the d-arabinose ligand, while compounds 3-5 are new 23-spirocholestane derivatives with a d-fucose ligand. The cytotoxic, anti-inflammatory, and anti-angiogenic activities of these isolated compounds were evaluated. Compound 5 showed anti-angiogenic activity in zebrafish embryos. | - |
dc.language | eng | - |
dc.relation.ispartof | New Journal of Chemistry | - |
dc.title | Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/d2nj04576a | - |
dc.identifier.scopus | eid_2-s2.0-85143850160 | - |
dc.identifier.volume | 47 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 324 | - |
dc.identifier.epage | 332 | - |
dc.identifier.eissn | 1369-9261 | - |