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Article: The effect of Andrographis paniculata water extract on palliative management of metastatic esophageal squamous cell carcinoma—A phase II clinical trial

TitleThe effect of Andrographis paniculata water extract on palliative management of metastatic esophageal squamous cell carcinoma—A phase II clinical trial
Authors
KeywordsAndrographis paniculata
esophageal squamous cell carcinoma
metastasis
overall survival
palliative management
Issue Date2023
Citation
Phytotherapy Research, 2023, v. 37, n. 8, p. 3438-3452 How to Cite?
AbstractPatients with metastatic esophageal squamous cell carcinoma (ESCC) have a grave prognosis with limited life expectancy. Here, a phase II clinical trial was conducted to investigate the effect of Andrographis paniculata (AP) on the palliative care of patients with metastatic ESCC. Patients with metastatic or locally advanced ESCC deemed unfit for surgery, and who have already completed palliative chemotherapy or chemoradiotherapy or are not fit for these treatments, were recruited. These patients were prescribed AP concentrated granules for 4 months. They also received clinical and quality of life assessments for clinical response, as well as positron emission tomography–computed tomography at 3 and 6 months after AP treatment for the assessment of tumor volume. Furthermore, the change in gut microbiota composition after AP treatment was studied. From the results, among the 30 recruited patients, 10 completed the entire course of AP treatment, while 20 received partial AP treatment. Patients who completed the AP treatment achieved significantly longer overall survival periods with the maintenance of the quality of life during the survival period when compared to those who could not complete AP treatment. The treatment effect of AP also contributed to the shift of the overall structure of gut microbiota for ESCC patients towards those of healthy individuals. The significance of this study is the establishment of AP as a safe and effective palliative treatment for patients with squamous cell carcinoma of the esophagus. To the best of our knowledge, this is the first clinical trial of AP water extract in esophageal cancer patients demonstrating its new medicinal use.
Persistent Identifierhttp://hdl.handle.net/10722/343417
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 1.277

 

DC FieldValueLanguage
dc.contributor.authorChiu, Philip Wai Yan-
dc.contributor.authorYue, Grace Gar Lee-
dc.contributor.authorCheung, Man Kit-
dc.contributor.authorYip, Hon Chi-
dc.contributor.authorChu, Siu Kai-
dc.contributor.authorYung, Man Yee-
dc.contributor.authorWu, Justin Che Yuen-
dc.contributor.authorChan, Shannon Melissa-
dc.contributor.authorTeoh, Anthony Yuen Bun-
dc.contributor.authorNg, Enders Kwok Wai-
dc.contributor.authorNorimoto, Hisayoshi-
dc.contributor.authorLau, Clara Bik San-
dc.date.accessioned2024-05-10T09:07:58Z-
dc.date.available2024-05-10T09:07:58Z-
dc.date.issued2023-
dc.identifier.citationPhytotherapy Research, 2023, v. 37, n. 8, p. 3438-3452-
dc.identifier.issn0951-418X-
dc.identifier.urihttp://hdl.handle.net/10722/343417-
dc.description.abstractPatients with metastatic esophageal squamous cell carcinoma (ESCC) have a grave prognosis with limited life expectancy. Here, a phase II clinical trial was conducted to investigate the effect of Andrographis paniculata (AP) on the palliative care of patients with metastatic ESCC. Patients with metastatic or locally advanced ESCC deemed unfit for surgery, and who have already completed palliative chemotherapy or chemoradiotherapy or are not fit for these treatments, were recruited. These patients were prescribed AP concentrated granules for 4 months. They also received clinical and quality of life assessments for clinical response, as well as positron emission tomography–computed tomography at 3 and 6 months after AP treatment for the assessment of tumor volume. Furthermore, the change in gut microbiota composition after AP treatment was studied. From the results, among the 30 recruited patients, 10 completed the entire course of AP treatment, while 20 received partial AP treatment. Patients who completed the AP treatment achieved significantly longer overall survival periods with the maintenance of the quality of life during the survival period when compared to those who could not complete AP treatment. The treatment effect of AP also contributed to the shift of the overall structure of gut microbiota for ESCC patients towards those of healthy individuals. The significance of this study is the establishment of AP as a safe and effective palliative treatment for patients with squamous cell carcinoma of the esophagus. To the best of our knowledge, this is the first clinical trial of AP water extract in esophageal cancer patients demonstrating its new medicinal use.-
dc.languageeng-
dc.relation.ispartofPhytotherapy Research-
dc.subjectAndrographis paniculata-
dc.subjectesophageal squamous cell carcinoma-
dc.subjectmetastasis-
dc.subjectoverall survival-
dc.subjectpalliative management-
dc.titleThe effect of Andrographis paniculata water extract on palliative management of metastatic esophageal squamous cell carcinoma—A phase II clinical trial-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ptr.7815-
dc.identifier.pmid37042309-
dc.identifier.scopuseid_2-s2.0-85152387515-
dc.identifier.volume37-
dc.identifier.issue8-
dc.identifier.spage3438-
dc.identifier.epage3452-
dc.identifier.eissn1099-1573-

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