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- Publisher Website: 10.1021/np4008969
- Scopus: eid_2-s2.0-84899545076
- PMID: 24761833
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Article: Potent airway smooth muscle relaxant effect of cynatratoside B, a steroidal glycoside isolated from cynanchum stauntonii
Title | Potent airway smooth muscle relaxant effect of cynatratoside B, a steroidal glycoside isolated from cynanchum stauntonii |
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Authors | |
Issue Date | 2014 |
Citation | Journal of Natural Products, 2014, v. 77, n. 4, p. 1074-1077 How to Cite? |
Abstract | The dried roots of Cynanchum stauntonii in having cough-relieving efficacy are commonly included in traditional antitussive formulas. The active components in a C. stauntonii root extract responsible for airway relaxation were isolated using an ex vivo bioassay-guided fractionation method, in which subfractions were evaluated for their inhibitory effects on the contraction of isolated rat tracheal rings by isometric tension measurements. A steroidal glycoside, cynatratoside B (1), identified by LC-MS and NMR spectroscopic analysis, was shown to have potent inhibition on acetylcholine- and carbachol-induced tracheal contractions. The present data provide scientific evidence to support the traditional use of C. stauntonii as an antitussive herbal medicine. © 2014 The American Chemical Society and American Society of Pharmacognosy. |
Persistent Identifier | http://hdl.handle.net/10722/343475 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 0.802 |
DC Field | Value | Language |
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dc.contributor.author | Yue, Grace Gar Lee | - |
dc.contributor.author | Chan, Kar Man | - |
dc.contributor.author | To, Ming Ho | - |
dc.contributor.author | Cheng, Ling | - |
dc.contributor.author | Fung, Kwok Pui | - |
dc.contributor.author | Leung, Ping Chung | - |
dc.contributor.author | Lau, Clara Bik San | - |
dc.date.accessioned | 2024-05-10T09:08:25Z | - |
dc.date.available | 2024-05-10T09:08:25Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Natural Products, 2014, v. 77, n. 4, p. 1074-1077 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343475 | - |
dc.description.abstract | The dried roots of Cynanchum stauntonii in having cough-relieving efficacy are commonly included in traditional antitussive formulas. The active components in a C. stauntonii root extract responsible for airway relaxation were isolated using an ex vivo bioassay-guided fractionation method, in which subfractions were evaluated for their inhibitory effects on the contraction of isolated rat tracheal rings by isometric tension measurements. A steroidal glycoside, cynatratoside B (1), identified by LC-MS and NMR spectroscopic analysis, was shown to have potent inhibition on acetylcholine- and carbachol-induced tracheal contractions. The present data provide scientific evidence to support the traditional use of C. stauntonii as an antitussive herbal medicine. © 2014 The American Chemical Society and American Society of Pharmacognosy. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Natural Products | - |
dc.title | Potent airway smooth muscle relaxant effect of cynatratoside B, a steroidal glycoside isolated from cynanchum stauntonii | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/np4008969 | - |
dc.identifier.pmid | 24761833 | - |
dc.identifier.scopus | eid_2-s2.0-84899545076 | - |
dc.identifier.volume | 77 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1074 | - |
dc.identifier.epage | 1077 | - |
dc.identifier.eissn | 1520-6025 | - |