File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma

TitleIn vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma
Authors
Keywords4T1 cells
Anti-metastasis
Anti-tumor
Bone destruction
Coriolus versicolor
Issue Date2014
Citation
Phytomedicine, 2014, v. 21, n. 8-9, p. 1078-1087 How to Cite?
AbstractCoriolus versicolor (CV), a medicinal mushroom widely consumed in Asian countries, has been demonstrated to be effective in stimulation of immune system and inhibition of tumor growth. The present study aimed to investigate the anti-tumor and anti-metastasis effects of CV aqueous extract in mouse mammary carcinoma 4T1 cells and in 4T1-tumor bearing mouse model. Our results showed that CV aqueous extract (0.125-2 mg/ml) did not inhibit 4T1 cell proliferation while the non-cytotoxic dose of CV extract (1-2 mg/ml) significantly inhibited cell migration and invasion (p < 0.05). Besides, the enzyme activities and protein levels of MMP-9 were suppressed by CV extract significantly. Animal studies showed that CV aqueous extract (1 g/kg, orally-fed daily for 4 weeks) was effective in decreasing the tumor weight by 36%, and decreased the lung metastasis by 70.8% against untreated control. Besides, micro-CT analysis of the tumor-bearing mice tibias indicated that CV extract was effective in bone protection against breast cancer-induced bone destruction as the bone volume was significantly increased. On the other hand, CV aqueous extract treatments resulted in remarkable immunomodulatory effects, which was reflected by the augmentation of IL-2, 6, 12, TNF-α and IFN-γ productions from the spleen lymphocytes of CV-treated tumor-bearing mice. In conclusion, our results demonstrated for the first time that the CV aqueous extract exhibited anti-tumor, anti-metastasis and immunomodulation effects in metastatic breast cancer mouse model, and could protect the bone from breast cancer-induced bone destruction. These findings provided scientific evidences for the clinical application of CV aqueous extract in breast cancer patients. © 2014 Elsevier GmbH.
Persistent Identifierhttp://hdl.handle.net/10722/343479
ISSN
2023 Impact Factor: 6.7
2023 SCImago Journal Rankings: 1.267

 

DC FieldValueLanguage
dc.contributor.authorLuo, Ke Wang-
dc.contributor.authorYue, Grace Gar Lee-
dc.contributor.authorKo, Chun Hay-
dc.contributor.authorLee, Julia Kin Ming-
dc.contributor.authorGao, Si-
dc.contributor.authorLi, Long Fei-
dc.contributor.authorLi, Gang-
dc.contributor.authorFung, Kwok Pui-
dc.contributor.authorLeung, Ping Chung-
dc.contributor.authorLau, Clara Bik San-
dc.date.accessioned2024-05-10T09:08:27Z-
dc.date.available2024-05-10T09:08:27Z-
dc.date.issued2014-
dc.identifier.citationPhytomedicine, 2014, v. 21, n. 8-9, p. 1078-1087-
dc.identifier.issn0944-7113-
dc.identifier.urihttp://hdl.handle.net/10722/343479-
dc.description.abstractCoriolus versicolor (CV), a medicinal mushroom widely consumed in Asian countries, has been demonstrated to be effective in stimulation of immune system and inhibition of tumor growth. The present study aimed to investigate the anti-tumor and anti-metastasis effects of CV aqueous extract in mouse mammary carcinoma 4T1 cells and in 4T1-tumor bearing mouse model. Our results showed that CV aqueous extract (0.125-2 mg/ml) did not inhibit 4T1 cell proliferation while the non-cytotoxic dose of CV extract (1-2 mg/ml) significantly inhibited cell migration and invasion (p < 0.05). Besides, the enzyme activities and protein levels of MMP-9 were suppressed by CV extract significantly. Animal studies showed that CV aqueous extract (1 g/kg, orally-fed daily for 4 weeks) was effective in decreasing the tumor weight by 36%, and decreased the lung metastasis by 70.8% against untreated control. Besides, micro-CT analysis of the tumor-bearing mice tibias indicated that CV extract was effective in bone protection against breast cancer-induced bone destruction as the bone volume was significantly increased. On the other hand, CV aqueous extract treatments resulted in remarkable immunomodulatory effects, which was reflected by the augmentation of IL-2, 6, 12, TNF-α and IFN-γ productions from the spleen lymphocytes of CV-treated tumor-bearing mice. In conclusion, our results demonstrated for the first time that the CV aqueous extract exhibited anti-tumor, anti-metastasis and immunomodulation effects in metastatic breast cancer mouse model, and could protect the bone from breast cancer-induced bone destruction. These findings provided scientific evidences for the clinical application of CV aqueous extract in breast cancer patients. © 2014 Elsevier GmbH.-
dc.languageeng-
dc.relation.ispartofPhytomedicine-
dc.subject4T1 cells-
dc.subjectAnti-metastasis-
dc.subjectAnti-tumor-
dc.subjectBone destruction-
dc.subjectCoriolus versicolor-
dc.titleIn vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.phymed.2014.04.020-
dc.identifier.pmid24856767-
dc.identifier.scopuseid_2-s2.0-84902003310-
dc.identifier.volume21-
dc.identifier.issue8-9-
dc.identifier.spage1078-
dc.identifier.epage1087-
dc.identifier.eissn1618-095X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats