File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1007/s00044-020-02506-7
- Scopus: eid_2-s2.0-85078617172
- Find via
Supplementary
-
Citations:
- Scopus: 0
- Appears in Collections:
Article: Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum
Title | Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum |
---|---|
Authors | |
Keywords | Colon cancer cells Cynanchum otophyllum Cytotoxicity Neurotrophic activity |
Issue Date | 2020 |
Citation | Medicinal Chemistry Research, 2020, v. 29, n. 3, p. 549-555 How to Cite? |
Abstract | Cynanchum otophyllum was traditionally used for treating muscle and skeletal pain, epilepsy, abdominal pain, and tightness. Four known C21 steroidal glycosides, namely caudatin 3-O-β-cymaropyranoside (1), caudatin 3-O-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside (2), otophylloside B (3), and otophylloside A (4) were isolated from the roots of this plant and their neurotrophic activities were examined in rat neuronal PC12 cell model, while their cytotoxicities were evaluated in human cancer cells and normal fibroblasts. Differential promoting effects on neurite-bearing cells were found among testing compounds, with 2 the most potent. On the other hand, selective cytotoxicity against human colon cancer cells HCT-116 of 2 was firstly demonstrated here. Besides, 2 induced inhibitory activities on cancer cell proliferation, sphere formation and interfered the cell cycle. The new potential pharmacological activities of 2 on colon cancer cells were revealed in the present study. |
Persistent Identifier | http://hdl.handle.net/10722/343492 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.410 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dong, Jinrun | - |
dc.contributor.author | Yue, Grace Gar Lee | - |
dc.contributor.author | Lee, Julia Kin Ming | - |
dc.contributor.author | Lau, Clara Bik San | - |
dc.contributor.author | Qiu, Minghua | - |
dc.date.accessioned | 2024-05-10T09:08:33Z | - |
dc.date.available | 2024-05-10T09:08:33Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Medicinal Chemistry Research, 2020, v. 29, n. 3, p. 549-555 | - |
dc.identifier.issn | 1054-2523 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343492 | - |
dc.description.abstract | Cynanchum otophyllum was traditionally used for treating muscle and skeletal pain, epilepsy, abdominal pain, and tightness. Four known C21 steroidal glycosides, namely caudatin 3-O-β-cymaropyranoside (1), caudatin 3-O-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside (2), otophylloside B (3), and otophylloside A (4) were isolated from the roots of this plant and their neurotrophic activities were examined in rat neuronal PC12 cell model, while their cytotoxicities were evaluated in human cancer cells and normal fibroblasts. Differential promoting effects on neurite-bearing cells were found among testing compounds, with 2 the most potent. On the other hand, selective cytotoxicity against human colon cancer cells HCT-116 of 2 was firstly demonstrated here. Besides, 2 induced inhibitory activities on cancer cell proliferation, sphere formation and interfered the cell cycle. The new potential pharmacological activities of 2 on colon cancer cells were revealed in the present study. | - |
dc.language | eng | - |
dc.relation.ispartof | Medicinal Chemistry Research | - |
dc.subject | Colon cancer cells | - |
dc.subject | Cynanchum otophyllum | - |
dc.subject | Cytotoxicity | - |
dc.subject | Neurotrophic activity | - |
dc.title | Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00044-020-02506-7 | - |
dc.identifier.scopus | eid_2-s2.0-85078617172 | - |
dc.identifier.volume | 29 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 549 | - |
dc.identifier.epage | 555 | - |
dc.identifier.eissn | 1554-8120 | - |