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Article: Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery
Title | Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery |
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Authors | |
Issue Date | 19-Mar-2024 |
Publisher | American Association for the Advancement of Science |
Citation | Science Signaling, 2024, v. 17, n. 828 How to Cite? |
Abstract | Post-exercise recovery is essential to resolve metabolic perturbations and promote long-term cellular remodeling in response to exercise. Here, we report that muscle-generated brain-derived neurotrophic factor (BDNF) elicits post-exercise recovery and metabolic reprogramming in skeletal muscle. BDNF increased the post-exercise expression of the gene encoding PPARδ (peroxisome proliferator-activated receptor δ), a transcription factor that is a master regulator of lipid metabolism. After exercise, mice with muscle-specific Bdnf knockout (MBKO) exhibited impairments in PPARδ-regulated metabolic gene expression, decreased intramuscular lipid content, reduced β-oxidation, and dysregulated mitochondrial dynamics. Moreover, MBKO mice required a longer period to recover from a bout of exercise and did not show increases in exercise-induced endurance capacity. Feeding naïve mice with the bioavailable BDNF mimetic 7,8-dihydroxyflavone resulted in effects that mimicked exercise-induced adaptations, including improved exercise capacity. Together, our findings reveal that BDNF is an essential myokine for exercise-induced metabolic recovery and remodeling in skeletal muscle. |
Persistent Identifier | http://hdl.handle.net/10722/344023 |
ISSN | 2023 Impact Factor: 6.7 2023 SCImago Journal Rankings: 2.341 |
DC Field | Value | Language |
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dc.contributor.author | Chan, Wing Suen | - |
dc.contributor.author | Ng, Chun Fai | - |
dc.contributor.author | Pang, Brian Pak Shing | - |
dc.contributor.author | Hang, Miaojia | - |
dc.contributor.author | Tse, Margaret Chui Ling | - |
dc.contributor.author | Iu, Elsie Chit Yu | - |
dc.contributor.author | Ooi, Xin Ci | - |
dc.contributor.author | Yang, Xiuying | - |
dc.contributor.author | Kim, Jason K | - |
dc.contributor.author | Lee, Chi Wai | - |
dc.contributor.author | Chan, Chi Bun | - |
dc.date.accessioned | 2024-06-25T03:29:56Z | - |
dc.date.available | 2024-06-25T03:29:56Z | - |
dc.date.issued | 2024-03-19 | - |
dc.identifier.citation | Science Signaling, 2024, v. 17, n. 828 | - |
dc.identifier.issn | 1945-0877 | - |
dc.identifier.uri | http://hdl.handle.net/10722/344023 | - |
dc.description.abstract | <p>Post-exercise recovery is essential to resolve metabolic perturbations and promote long-term cellular remodeling in response to exercise. Here, we report that muscle-generated brain-derived neurotrophic factor (BDNF) elicits post-exercise recovery and metabolic reprogramming in skeletal muscle. BDNF increased the post-exercise expression of the gene encoding PPARδ (peroxisome proliferator-activated receptor δ), a transcription factor that is a master regulator of lipid metabolism. After exercise, mice with muscle-specific <em>Bdnf</em> knockout (<em>MBKO</em>) exhibited impairments in PPARδ-regulated metabolic gene expression, decreased intramuscular lipid content, reduced β-oxidation, and dysregulated mitochondrial dynamics. Moreover, <em>MBKO</em> mice required a longer period to recover from a bout of exercise and did not show increases in exercise-induced endurance capacity. Feeding naïve mice with the bioavailable BDNF mimetic 7,8-dihydroxyflavone resulted in effects that mimicked exercise-induced adaptations, including improved exercise capacity. Together, our findings reveal that BDNF is an essential myokine for exercise-induced metabolic recovery and remodeling in skeletal muscle.<br></p> | - |
dc.language | eng | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.ispartof | Science Signaling | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/scisignal.adh2783 | - |
dc.identifier.scopus | eid_2-s2.0-85188319790 | - |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 828 | - |
dc.identifier.eissn | 1937-9145 | - |
dc.identifier.issnl | 1945-0877 | - |