Effect of strontium enriched calcium phosphate cement on the healing of osteoporotic fracture in a rat distal femur bone defect model

Abstract

Calcium Phosphate Cement (CPC) is a unique material to repair bone defect. This study characterizes the impact of adding Strontium (Sr) to CPC. Few important aspects include the increase of compressive strength and compressive modulus of SrCPC bone cement. Also, the overall degradability of SrCPC bone cement is not affected by the addition of Sr ions on the surface of bone cement. Through in vitro study of SrCPC, we showed that the release of active ingredients from 10% SrCPC does not result in a significant osteogenic differentiation. Through in vivo study of SrCPC, we showed that SrCPC degrades slower than CPC group, regenerates bone at a volume more significant than other groups and was able to maintain its cement volume in the defect region consistently more so from week 0 to week 6.