File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Potential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine

TitlePotential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine
Authors
Chen, FeiyuZhong, ZhangfengZhang, ChengLu, YuanjunChan, Yau TuenWang, NingZhao, DiFeng, Yibin
KeywordsFAK
FAK inhibitors
metastasis
natural compounds
Src
tumor
Issue Date1-Nov-2022
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Citation
International Journal of Molecular Sciences, 2022, v. 23, n. 21 How to Cite?
DOI: http://dx.doi.org/10.3390/ijms232113334
Abstract

Focal adhesion kinase (FAK) is a multifunctional protein involved in cellular communication, integrating and transducing extracellular signals from cell-surface membrane receptors. It plays a central role intracellularly and extracellularly within the tumor microenvironment. Perturbations in FAK signaling promote tumor occurrence and development, and studies have revealed its biological behavior in tumor cell proliferation, migration, and adhesion. Herein we provide an overview of the complex biology of the FAK family members and their context-dependent nature. Next, with a focus on cancer, we highlight the activities of FAK signaling in different types of cancer and how knowledge of them is being used for screening natural compounds used in herbal medicine to fight tumor development.


Persistent Identifierhttp://hdl.handle.net/10722/344288
ISSN
1661-6596
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179

 

DC FieldValueLanguage
dc.contributor.authorChen, Feiyu-
dc.contributor.authorZhong, Zhangfeng-
dc.contributor.authorZhang, Cheng-
dc.contributor.authorLu, Yuanjun-
dc.contributor.authorChan, Yau Tuen-
dc.contributor.authorWang, Ning-
dc.contributor.authorZhao, Di-
dc.contributor.authorFeng, Yibin-
dc.date.accessioned2024-07-16T03:42:17Z-
dc.date.available2024-07-16T03:42:17Z-
dc.date.issued2022-11-01-
dc.identifier.citationInternational Journal of Molecular Sciences, 2022, v. 23, n. 21-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/344288-
dc.description.abstract<p>Focal adhesion kinase (FAK) is a multifunctional protein involved in cellular communication, integrating and transducing extracellular signals from cell-surface membrane receptors. It plays a central role intracellularly and extracellularly within the tumor microenvironment. Perturbations in FAK signaling promote tumor occurrence and development, and studies have revealed its biological behavior in tumor cell proliferation, migration, and adhesion. Herein we provide an overview of the complex biology of the FAK family members and their context-dependent nature. Next, with a focus on cancer, we highlight the activities of FAK signaling in different types of cancer and how knowledge of them is being used for screening natural compounds used in herbal medicine to fight tumor development.</p>-
dc.languageeng-
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectFAK-
dc.subjectFAK inhibitors-
dc.subjectmetastasis-
dc.subjectnatural compounds-
dc.subjectSrc-
dc.subjecttumor-
dc.titlePotential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine-
dc.typeArticle-
dc.identifier.doi10.3390/ijms232113334-
dc.identifier.pmid36362132-
dc.identifier.scopuseid_2-s2.0-85141620511-
dc.identifier.volume23-
dc.identifier.issue21-
dc.identifier.eissn1422-0067-
dc.identifier.issnl1422-0067-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats