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Article: Hallmarks of cancer stemness

TitleHallmarks of cancer stemness
Authors
Loh, Jia-JianMa, Stephanie
Keywordscancer cell plasticity
cancer stem cells
cancer stemness
immunosuppression
metastasis
self-renewal
tumor microenvironment
tumor recurrence
tumor-initiating cells
Issue Date2-May-2024
PublisherElsevier
Citation
Cell Stem Cell, 2024, v. 31, n. 5, p. 617-639 How to Cite?
DOI: http://dx.doi.org/10.1016/j.stem.2024.04.004
Abstract

Cancer stemness is recognized as a key component of tumor development. Previously coined “cancer stem cells” (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC-niche interplay. This revelation underscores the need to reevaluate the hallmarks of cancer stemness. Herein, we summarize the techniques used to identify and characterize the state of these cells and discuss their defining and emerging hallmarks, along with their enabling and associated features. We also highlight potential future directions in this field of research.


Persistent Identifierhttp://hdl.handle.net/10722/344327
ISSN
1934-5909
2023 Impact Factor: 19.8
2023 SCImago Journal Rankings: 10.253

 

DC FieldValueLanguage
dc.contributor.authorLoh, Jia-Jian-
dc.contributor.authorMa, Stephanie-
dc.date.accessioned2024-07-24T13:50:46Z-
dc.date.available2024-07-24T13:50:46Z-
dc.date.issued2024-05-02-
dc.identifier.citationCell Stem Cell, 2024, v. 31, n. 5, p. 617-639-
dc.identifier.issn1934-5909-
dc.identifier.urihttp://hdl.handle.net/10722/344327-
dc.description.abstract<p>Cancer stemness is recognized as a key component of tumor development. Previously coined “cancer stem cells” (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC-niche interplay. This revelation underscores the need to reevaluate the hallmarks of cancer stemness. Herein, we summarize the techniques used to identify and characterize the state of these cells and discuss their defining and emerging hallmarks, along with their enabling and associated features. We also highlight potential future directions in this field of research.<br></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofCell Stem Cell-
dc.subjectcancer cell plasticity-
dc.subjectcancer stem cells-
dc.subjectcancer stemness-
dc.subjectimmunosuppression-
dc.subjectmetastasis-
dc.subjectself-renewal-
dc.subjecttumor microenvironment-
dc.subjecttumor recurrence-
dc.subjecttumor-initiating cells-
dc.titleHallmarks of cancer stemness-
dc.typeArticle-
dc.identifier.doi10.1016/j.stem.2024.04.004-
dc.identifier.scopuseid_2-s2.0-85190956215-
dc.identifier.volume31-
dc.identifier.issue5-
dc.identifier.spage617-
dc.identifier.epage639-
dc.identifier.eissn1875-9777-
dc.identifier.issnl1875-9777-

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