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Article: The multifaceted roles of small extracellular vesicles in metabolic reprogramming in the tumor microenvironments

TitleThe multifaceted roles of small extracellular vesicles in metabolic reprogramming in the tumor microenvironments
Authors
Keywordssmall extracellular vesicles
tumor microenvironment
Issue Date1-Jun-2024
PublisherWiley
Citation
Proteomics, 2024, v. 24, n. 11 How to Cite?
Abstract

The link between metabolism and tumor progression has been extensively researched for a long time. With the increasing number of studies uncovering the multiple functions of metabolic reprogramming in tumor microenvironments, the regulatory network seems to become even more intricate at the same time. Small extracellular vesicles (sEV), as crucial mediators facilitating intercellular communications, exhibit significant involvement in regulating metabolic reprogramming within the complicated network of tumor microenvironments. sEV derived from tumor cells and those released by other cell populations such as tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) can mutually influence each other, giving rise to diverse complex feedback loops. This review includes multiple studies conducted in recent years to summarize the functions of sEV in altering metabolism in various cell types within tumor microenvironments. Additionally, it aims to highlight potential therapeutic targets based on the commonly observed mechanisms identified in different studies.


Persistent Identifierhttp://hdl.handle.net/10722/344359
ISSN
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 1.011

 

DC FieldValueLanguage
dc.contributor.authorChen, Zhixian-
dc.contributor.authorYam, Judy Wai Ping-
dc.contributor.authorMao, Xiaowen-
dc.date.accessioned2024-07-24T13:50:59Z-
dc.date.available2024-07-24T13:50:59Z-
dc.date.issued2024-06-01-
dc.identifier.citationProteomics, 2024, v. 24, n. 11-
dc.identifier.issn1615-9853-
dc.identifier.urihttp://hdl.handle.net/10722/344359-
dc.description.abstract<p>The link between metabolism and tumor progression has been extensively researched for a long time. With the increasing number of studies uncovering the multiple functions of metabolic reprogramming in tumor microenvironments, the regulatory network seems to become even more intricate at the same time. Small extracellular vesicles (sEV), as crucial mediators facilitating intercellular communications, exhibit significant involvement in regulating metabolic reprogramming within the complicated network of tumor microenvironments. sEV derived from tumor cells and those released by other cell populations such as tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) can mutually influence each other, giving rise to diverse complex feedback loops. This review includes multiple studies conducted in recent years to summarize the functions of sEV in altering metabolism in various cell types within tumor microenvironments. Additionally, it aims to highlight potential therapeutic targets based on the commonly observed mechanisms identified in different studies.</p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofProteomics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectsmall extracellular vesicles-
dc.subjecttumor microenvironment-
dc.titleThe multifaceted roles of small extracellular vesicles in metabolic reprogramming in the tumor microenvironments -
dc.typeArticle-
dc.identifier.doi10.1002/pmic.202300021-
dc.identifier.scopuseid_2-s2.0-85181249632-
dc.identifier.volume24-
dc.identifier.issue11-
dc.identifier.eissn1615-9861-
dc.identifier.issnl1615-9853-

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