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- Publisher Website: 10.1016/j.psyneuen.2024.107116
- Scopus: eid_2-s2.0-85197531536
- PMID: 38981200
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Article: Is social disadvantage a chronic stressor? Socioeconomic position and HPA axis activity among older adults living in England
| Title | Is social disadvantage a chronic stressor? Socioeconomic position and HPA axis activity among older adults living in England |
|---|---|
| Authors | |
| Keywords | Cortisol Cortisone Missing data Socioeconomic position |
| Issue Date | 28-Jun-2024 |
| Publisher | Elsevier |
| Citation | Psychoneuroendocrinology, 2024, v. 168 How to Cite? |
| Abstract | IntroductionLiving in socioeconomic disadvantage has been conceptualised as a chronic stressor, although this contradicts evidence from studies using hair cortisol and cortisone as a measure of hypothalamus-pituitary-adrenal (HPA)1 axis activity. These studies used complete case analyses, ignoring the impact of missing data for inference, despite the high proportion of missing biomarker data. The methodological limitations of studies investigating the association between socioeconomic position (SEP)2 defined as education, wealth, and social class and hair cortisol and cortisone are considered in this study by comparing three common methods to deal with missing data: (1) Complete Case Analysis (CCA),3 (2) Inverse Probability Weighting (IPW) 4and (3) weighted Multiple Imputation (MI).5 This study examines if socioeconomic disadvantage is associated with higher levels of HPA axis activity as measured by hair cortisol and cortisone among older adults using three approaches for compensating for missing data. MethodCortisol and cortisone levels in hair samples from 4573 participants in the 6th wave (2012–2013) of the English Longitudinal Study of Ageing (ELSA)6 were examined, in relation to education, wealth, and social class. We compared linear regression models with CCA, weighted and multiple imputed weighted linear regression models. ResultsSocial groups with certain characteristics (i.e., ethnic minorities, in routine and manual occupations, physically inactive, with poorer health, and smokers) were less likely to have hair cortisol and hair cortisone data compared to the most advantaged groups. We found a consistent pattern of higher levels of hair cortisol and cortisone among the most socioeconomically disadvantaged groups compared to the most advantaged groups. Complete case approaches to missing data underestimated the levels of hair cortisol in education and social class and the levels of hair cortisone in education, wealth, and social class in the most disadvantaged groups. ConclusionThis study demonstrates that social disadvantage as measured by disadvantaged SEP is associated with increased HPA axis activity. The conceptualisation of social disadvantage as a chronic stressor may be valid and previous studies reporting no associations between SEP and hair cortisol may be biased due to their lack of consideration of missing data cases which showed the underrepresentation of disadvantaged social groups in the analyses. Future analyses using biosocial data may need to consider and adjust for missing data. |
| Persistent Identifier | http://hdl.handle.net/10722/344678 |
| ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 1.373 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chatzi, G | - |
| dc.contributor.author | Chandola, T | - |
| dc.contributor.author | Shlomo, N | - |
| dc.contributor.author | Cernat, A | - |
| dc.contributor.author | Hannemann, T | - |
| dc.date.accessioned | 2024-07-31T06:22:58Z | - |
| dc.date.available | 2024-07-31T06:22:58Z | - |
| dc.date.issued | 2024-06-28 | - |
| dc.identifier.citation | Psychoneuroendocrinology, 2024, v. 168 | - |
| dc.identifier.issn | 0306-4530 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/344678 | - |
| dc.description.abstract | <h3>Introduction</h3><p>Living in socioeconomic disadvantage has been conceptualised as a <a href="https://www.sciencedirect.com/topics/psychology/chronic-stressor" title="Learn more about chronic stressor from ScienceDirect's AI-generated Topic Pages">chronic stressor</a>, although this contradicts evidence from studies using hair <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/hydrocortisone" title="Learn more about cortisol from ScienceDirect's AI-generated Topic Pages">cortisol</a> and <a href="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cortisone" title="Learn more about cortisone from ScienceDirect's AI-generated Topic Pages">cortisone</a> as a measure of hypothalamus-pituitary-adrenal (HPA)<a href="https://www.sciencedirect.com/science/article/pii/S0306453024001604?via%3Dihub#fn1"><sup>1</sup></a> axis activity. These studies used complete case analyses, ignoring the impact of missing data for inference, despite the high proportion of missing biomarker data. The methodological limitations of studies investigating the association between socioeconomic position (SEP)<a href="https://www.sciencedirect.com/science/article/pii/S0306453024001604?via%3Dihub#fn2"><sup>2</sup></a> defined as education, wealth, and social class and hair <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/hydrocortisone" title="Learn more about cortisol from ScienceDirect's AI-generated Topic Pages">cortisol</a> and <a href="https://www.sciencedirect.com/topics/neuroscience/cortisone" title="Learn more about cortisone from ScienceDirect's AI-generated Topic Pages">cortisone</a> are considered in this study by comparing three common methods to deal with missing data: (1) Complete Case Analysis (CCA),<a href="https://www.sciencedirect.com/science/article/pii/S0306453024001604?via%3Dihub#fn3"><sup>3</sup></a> (2) Inverse Probability Weighting (IPW) <a href="https://www.sciencedirect.com/science/article/pii/S0306453024001604?via%3Dihub#fn4"><sup>4</sup></a>and (3) weighted Multiple Imputation (MI).<a href="https://www.sciencedirect.com/science/article/pii/S0306453024001604?via%3Dihub#fn5"><sup>5</sup></a> This study examines if socioeconomic disadvantage is associated with higher levels of HPA axis activity as measured by hair cortisol and <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/cortisone" title="Learn more about cortisone from ScienceDirect's AI-generated Topic Pages">cortisone</a> among older adults using three approaches for compensating for missing data.</p><h3>Method</h3><p>Cortisol and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cortisone" title="Learn more about cortisone from ScienceDirect's AI-generated Topic Pages">cortisone</a> levels in hair samples from 4573 participants in the 6th wave (2012–2013) of the English Longitudinal Study of Ageing (ELSA)<a href="https://www.sciencedirect.com/science/article/pii/S0306453024001604?via%3Dihub#fn6"><sup>6</sup></a> were examined, in relation to education, wealth, and social class. We compared <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/linear-regression-analysis" title="Learn more about linear regression from ScienceDirect's AI-generated Topic Pages">linear regression</a> models with CCA, weighted and multiple imputed weighted linear regression models.</p><h3>Results</h3><p>Social groups with certain characteristics (i.e., ethnic minorities, in routine and manual occupations, physically inactive, with poorer health, and smokers) were less likely to have hair cortisol and hair <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/cortisone" title="Learn more about cortisone from ScienceDirect's AI-generated Topic Pages">cortisone</a> data compared to the most advantaged groups. We found a consistent pattern of higher levels of hair cortisol and cortisone among the most socioeconomically disadvantaged groups compared to the most advantaged groups. Complete case approaches to missing data underestimated the levels of hair cortisol in education and social class and the levels of hair cortisone in education, wealth, and social class in the most disadvantaged groups.</p><h3>Conclusion</h3><p>This study demonstrates that social disadvantage as measured by disadvantaged SEP is associated with increased HPA axis activity. The conceptualisation of social disadvantage as a chronic stressor may be valid and previous studies reporting no associations between SEP and hair cortisol may be biased due to their lack of consideration of missing data cases which showed the underrepresentation of disadvantaged social groups in the analyses. Future analyses using biosocial data may need to consider and adjust for missing data.<br></p> | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation.ispartof | Psychoneuroendocrinology | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | Cortisol | - |
| dc.subject | Cortisone | - |
| dc.subject | Missing data | - |
| dc.subject | Socioeconomic position | - |
| dc.title | Is social disadvantage a chronic stressor? Socioeconomic position and HPA axis activity among older adults living in England | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1016/j.psyneuen.2024.107116 | - |
| dc.identifier.pmid | 38981200 | - |
| dc.identifier.scopus | eid_2-s2.0-85197531536 | - |
| dc.identifier.volume | 168 | - |
| dc.identifier.eissn | 1873-3360 | - |
| dc.identifier.issnl | 0306-4530 | - |