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Article: A neurofunctional signature of subjective disgust generalizes to oral distaste and socio-moral contexts

TitleA neurofunctional signature of subjective disgust generalizes to oral distaste and socio-moral contexts
Authors
Issue Date19-Apr-2024
PublisherNature Research
Citation
Nature Human Behaviour, 2024, v. 8, n. 7, p. 1383-1402 How to Cite?
Abstract

While disgust originates in the hard-wired mammalian distaste response, the conscious experience of disgust in humans strongly depends on subjective appraisal and may even extend to socio-moral contexts. Here, in a series of studies, we combined functional magnetic resonance imaging with machine-learning-based predictive modelling to establish a comprehensive neurobiological model of subjective disgust. The developed neurofunctional signature accurately predicted momentary self-reported subjective disgust across discovery (n = 78) and pre-registered validation (n = 30) cohorts and generalized across core disgust (n = 34 and n = 26), gustatory distaste (n = 30) and socio-moral (unfair offers; n = 43) contexts. Disgust experience was encoded in distributed cortical and subcortical systems, and exhibited distinct and shared neural representations with subjective fear or negative affect in interoceptive-emotional awareness and conscious appraisal systems, while the signatures most accurately predicted the respective target experience. We provide an accurate functional magnetic resonance imaging signature for disgust with a high potential to resolve ongoing evolutionary debates.


Persistent Identifierhttp://hdl.handle.net/10722/344879
ISSN
2023 Impact Factor: 21.4
2023 SCImago Journal Rankings: 6.097
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGan, Xianyang-
dc.contributor.authorZhou, Feng-
dc.contributor.authorXu, Ting-
dc.contributor.authorLiu, Xiaobo-
dc.contributor.authorZhang, Ran-
dc.contributor.authorZheng, Zihao-
dc.contributor.authorYang, Xi-
dc.contributor.authorZhou, Xinqi-
dc.contributor.authorYu, Fangwen-
dc.contributor.authorLi, Jialin-
dc.contributor.authorCui, Ruifang-
dc.contributor.authorWang, Lan-
dc.contributor.authorYuan, Jiajin-
dc.contributor.authorYao, Dezhong-
dc.contributor.authorBecker, Benjamin-
dc.date.accessioned2024-08-12T04:08:05Z-
dc.date.available2024-08-12T04:08:05Z-
dc.date.issued2024-04-19-
dc.identifier.citationNature Human Behaviour, 2024, v. 8, n. 7, p. 1383-1402-
dc.identifier.issn2397-3374-
dc.identifier.urihttp://hdl.handle.net/10722/344879-
dc.description.abstract<p>While disgust originates in the hard-wired mammalian distaste response, the conscious experience of disgust in humans strongly depends on subjective appraisal and may even extend to socio-moral contexts. Here, in a series of studies, we combined functional magnetic resonance imaging with machine-learning-based predictive modelling to establish a comprehensive neurobiological model of subjective disgust. The developed neurofunctional signature accurately predicted momentary self-reported subjective disgust across discovery (<em>n</em> = 78) and pre-registered validation (<em>n</em> = 30) cohorts and generalized across core disgust (<em>n</em> = 34 and <em>n</em> = 26), gustatory distaste (<em>n</em> = 30) and socio-moral (unfair offers; <em>n</em> = 43) contexts. Disgust experience was encoded in distributed cortical and subcortical systems, and exhibited distinct and shared neural representations with subjective fear or negative affect in interoceptive-emotional awareness and conscious appraisal systems, while the signatures most accurately predicted the respective target experience. We provide an accurate functional magnetic resonance imaging signature for disgust with a high potential to resolve ongoing evolutionary debates.<br></p>-
dc.languageeng-
dc.publisherNature Research-
dc.relation.ispartofNature Human Behaviour-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleA neurofunctional signature of subjective disgust generalizes to oral distaste and socio-moral contexts-
dc.typeArticle-
dc.identifier.doi10.1038/s41562-024-01868-x-
dc.identifier.scopuseid_2-s2.0-85190764113-
dc.identifier.volume8-
dc.identifier.issue7-
dc.identifier.spage1383-
dc.identifier.epage1402-
dc.identifier.eissn2397-3374-
dc.identifier.isiWOS:001205254300001-
dc.identifier.issnl2397-3374-

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