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Article: Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: Results from the EU-GEI case-control study

TitleCannabis use as a potential mediator between childhood adversity and first-episode psychosis: Results from the EU-GEI case-control study
Authors
KeywordsCannabis use
childhood experience
mediation
psychotic disorders
trauma
Issue Date4-May-2023
PublisherCambridge University Press
Citation
Psychological Medicine, 2023, v. 53, n. 15, p. 7375-7384 How to Cite?
Abstract

Background: Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. Methods: Data were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0-11 years), and late (12-17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. Results: The association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. Conclusions: Harmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse.


Persistent Identifierhttp://hdl.handle.net/10722/345774
ISSN
2023 Impact Factor: 5.9
2023 SCImago Journal Rankings: 2.768

 

DC FieldValueLanguage
dc.contributor.authorTrotta, Giulia-
dc.contributor.authorRodriguez, Victoria-
dc.contributor.authorQuattrone, Diego-
dc.contributor.authorSpinazzola, Edoardo-
dc.contributor.authorTripoli, Giada-
dc.contributor.authorGayer-Anderson, Charlotte-
dc.contributor.authorFreeman, Tom P-
dc.contributor.authorJongsma, Hannah E-
dc.contributor.authorSideli, Lucia-
dc.contributor.authorAas, Monica-
dc.contributor.authorStilo, Simona A-
dc.contributor.authorLa Cascia, Caterina-
dc.contributor.authorFerraro, Laura-
dc.contributor.authorLa Barbera, Daniele-
dc.contributor.authorLasalvia, Antonio-
dc.contributor.authorTosato, Sarah-
dc.contributor.authorTarricone, Ilaria-
dc.contributor.authorD'Andrea, Giuseppe-
dc.contributor.authorTortelli, Andrea-
dc.contributor.authorSchürhoff, Franck-
dc.contributor.authorSzöke, Andrei-
dc.contributor.authorPignon, Baptiste-
dc.contributor.authorSelten, Jean Paul-
dc.contributor.authorVelthorst, Eva-
dc.contributor.authorDe Haan, Lieuwe-
dc.contributor.authorLlorca, Pierre Michel-
dc.contributor.authorRossi Menezes, Paulo-
dc.contributor.authorDel Ben, Cristina M.-
dc.contributor.authorSantos, Jose Luis-
dc.contributor.authorArrojo, Manuel-
dc.contributor.authorBobes, Julio-
dc.contributor.authorSanjuán, Julio-
dc.contributor.authorBernardo, Miquel-
dc.contributor.authorArango, Celso-
dc.contributor.authorKirkbride, James B-
dc.contributor.authorJones, Peter B-
dc.contributor.authorRichards, Alexander-
dc.contributor.authorRutten, Bart P-
dc.contributor.authorVan Os, Jim-
dc.contributor.authorAustin-Zimmerman, Isabelle-
dc.contributor.authorLi, Zhikun-
dc.contributor.authorMorgan, Craig-
dc.contributor.authorSham, Pak C-
dc.contributor.authorVassos, Evangelos-
dc.contributor.authorWong, Chloe-
dc.contributor.authorBentall, Richard-
dc.contributor.authorFisher, Helen L-
dc.contributor.authorMurray, Robin M-
dc.contributor.authorAlameda, Luis-
dc.contributor.authorDi Forti, Marta-
dc.date.accessioned2024-08-28T07:40:37Z-
dc.date.available2024-08-28T07:40:37Z-
dc.date.issued2023-05-04-
dc.identifier.citationPsychological Medicine, 2023, v. 53, n. 15, p. 7375-7384-
dc.identifier.issn0033-2917-
dc.identifier.urihttp://hdl.handle.net/10722/345774-
dc.description.abstract<p>Background: Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. Methods: Data were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0-11 years), and late (12-17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. Results: The association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. Conclusions: Harmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse.</p>-
dc.languageeng-
dc.publisherCambridge University Press-
dc.relation.ispartofPsychological Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCannabis use-
dc.subjectchildhood experience-
dc.subjectmediation-
dc.subjectpsychotic disorders-
dc.subjecttrauma-
dc.titleCannabis use as a potential mediator between childhood adversity and first-episode psychosis: Results from the EU-GEI case-control study-
dc.typeArticle-
dc.identifier.doi10.1017/S0033291723000995-
dc.identifier.pmid38078747-
dc.identifier.scopuseid_2-s2.0-85179647128-
dc.identifier.volume53-
dc.identifier.issue15-
dc.identifier.spage7375-
dc.identifier.epage7384-
dc.identifier.eissn1469-8978-
dc.identifier.issnl0033-2917-

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