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Conference Paper: The dynamic responses of in vitro primary retinal ganglion cells (RGCs) induced by pulsatile pressure stimuli
| Title | The dynamic responses of in vitro primary retinal ganglion cells (RGCs) induced by pulsatile pressure stimuli |
|---|---|
| Authors | |
| Issue Date | 5-Jun-2024 |
| Publisher | Association for Research in Vision and Ophthalmology |
| Abstract | significantly under NP at 48h (1.5±0.5 times, p=0.001). Sa showed no significant difference in or between NP and FNP. Additionally, microtubule aggregation into segments in neurites was observed in both FNP at 72h and EP at 48h, followed by neurite beading in EP at 72h. Conclusions : The pressure fluctuation (±2.5 mmHg) with a normal baseline IOP (i.e. 14 mmHg) range would contribute to inhibition of the neurite growth, which is comparable with the RGC responses to constant AHP. This finding indicates that the pulsatile IOP potentially triggers degeneration of RGCs. Further investigation will be needed to better understand the relationship between pressure fluctuation range and RGC degeneration. |
| Persistent Identifier | http://hdl.handle.net/10722/347871 |
| ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 1.422 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Li, Qinyu | - |
| dc.contributor.author | Mak, Heather Kayew | - |
| dc.contributor.author | Leung, Christopher Kai-Shun | - |
| dc.contributor.author | Chan, Yau Kei | - |
| dc.date.accessioned | 2024-10-01T00:30:52Z | - |
| dc.date.available | 2024-10-01T00:30:52Z | - |
| dc.date.issued | 2024-06-05 | - |
| dc.identifier.issn | 0146-0404 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/347871 | - |
| dc.description.abstract | <p>significantly under NP at 48h (1.5±0.5 times, p=0.001). Sa showed no significant difference in or between NP and FNP. Additionally, microtubule aggregation into segments in neurites was observed in both FNP at 72h and EP at 48h, followed by neurite beading in EP at 72h.</p><p><br></p><p>Conclusions : The pressure fluctuation (±2.5 mmHg) with a normal baseline IOP (i.e. 14 mmHg) range would contribute to inhibition of the neurite growth, which is comparable with the RGC responses to constant AHP. This finding indicates that the pulsatile IOP potentially triggers degeneration of RGCs. Further investigation will be needed to better understand the relationship between pressure fluctuation range and RGC degeneration.</p> | - |
| dc.language | eng | - |
| dc.publisher | Association for Research in Vision and Ophthalmology | - |
| dc.relation.ispartof | Investigative Ophthalmology & Visual Science | - |
| dc.title | The dynamic responses of in vitro primary retinal ganglion cells (RGCs) induced by pulsatile pressure stimuli | - |
| dc.type | Conference_Paper | - |
| dc.identifier.volume | 65 | - |
| dc.identifier.issue | 7 | - |
| dc.identifier.eissn | 1552-5783 | - |
| dc.identifier.issnl | 0146-0404 | - |