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- Publisher Website: 10.3390/ijms25126403
- Scopus: eid_2-s2.0-85197152700
- PMID: 38928110
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Article: Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity
Title | Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity |
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Authors | |
Keywords | cancer therapy histone chaperone targeted therapies |
Issue Date | 10-Jun-2024 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
Citation | International Journal of Molecular Sciences, 2024, v. 25, n. 12 How to Cite? |
Abstract | Histone chaperones are integral to chromatin dynamics, facilitating the assembly and disassembly of nucleosomes, thereby playing a crucial role in regulating gene expression and maintaining genomic stability. Moreover, they prevent aberrant histone interactions prior to chromatin assembly. Disruption in histone chaperone function may result in genomic instability, which is implicated in pathogenesis. This review aims to elucidate the role of histone chaperones in cancer pathologies and explore their potential as therapeutic targets. Histone chaperones have been found to be dysregulated in various cancers, with alterations in expression levels, mutations, or aberrant interactions leading to tumorigenesis and cancer progression. In addition, this review intends to highlight the molecular mechanisms of interactions between histone chaperones and oncogenic factors, underscoring their roles in cancer cell survival and proliferation. The dysregulation of histone chaperones is significantly correlated with cancer development, establishing them as active contributors to cancer pathology and viable targets for therapeutic intervention. This review advocates for continued research into histone chaperone-targeted therapies, which hold potential for precision medicine in oncology. Future advancements in understanding chaperone functions and interactions are anticipated to lead to novel cancer treatments, enhancing patient care and outcomes. |
Persistent Identifier | http://hdl.handle.net/10722/348311 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
DC Field | Value | Language |
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dc.contributor.author | Lee, Jiho | - |
dc.contributor.author | Bao, Xiucong | - |
dc.date.accessioned | 2024-10-08T00:31:34Z | - |
dc.date.available | 2024-10-08T00:31:34Z | - |
dc.date.issued | 2024-06-10 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2024, v. 25, n. 12 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/348311 | - |
dc.description.abstract | Histone chaperones are integral to chromatin dynamics, facilitating the assembly and disassembly of nucleosomes, thereby playing a crucial role in regulating gene expression and maintaining genomic stability. Moreover, they prevent aberrant histone interactions prior to chromatin assembly. Disruption in histone chaperone function may result in genomic instability, which is implicated in pathogenesis. This review aims to elucidate the role of histone chaperones in cancer pathologies and explore their potential as therapeutic targets. Histone chaperones have been found to be dysregulated in various cancers, with alterations in expression levels, mutations, or aberrant interactions leading to tumorigenesis and cancer progression. In addition, this review intends to highlight the molecular mechanisms of interactions between histone chaperones and oncogenic factors, underscoring their roles in cancer cell survival and proliferation. The dysregulation of histone chaperones is significantly correlated with cancer development, establishing them as active contributors to cancer pathology and viable targets for therapeutic intervention. This review advocates for continued research into histone chaperone-targeted therapies, which hold potential for precision medicine in oncology. Future advancements in understanding chaperone functions and interactions are anticipated to lead to novel cancer treatments, enhancing patient care and outcomes. | - |
dc.language | eng | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | cancer therapy | - |
dc.subject | histone chaperone | - |
dc.subject | targeted therapies | - |
dc.title | Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity | - |
dc.type | Article | - |
dc.description.nature | preprint | - |
dc.identifier.doi | 10.3390/ijms25126403 | - |
dc.identifier.pmid | 38928110 | - |
dc.identifier.scopus | eid_2-s2.0-85197152700 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 12 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.issnl | 1422-0067 | - |