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Article: Potentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease

TitlePotentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease
Authors
Keywordsantioxidants
chronic kidney disease
inflammation
oxidative stress
renal preservation
Issue Date20-Jun-2024
PublisherMDPI
Citation
Antioxidants, 2024, v. 13, n. 6 How to Cite?
Abstract

Chronic kidney disease (CKD) presents a substantial global public health challenge, with high morbidity and mortality. CKD patients often experience dyslipidaemia and poor glycaemic control, further exacerbating inflammation and oxidative stress in the kidney. If left untreated, these metabolic symptoms can progress to end-stage renal disease, necessitating long-term dialysis or kidney transplantation. Alleviating inflammation responses has become the standard approach in CKD management. Medications such as statins, metformin, and GLP-1 agonists, initially developed for treating metabolic dysregulation, demonstrate promising renal therapeutic benefits. The rising popularity of herbal remedies and supplements, perceived as natural antioxidants, has spurred investigations into their potential efficacy. Notably, lactoferrin, Boerhaavia diffusa, Amauroderma rugosum, and Ganoderma lucidum are known for their anti-inflammatory and antioxidant properties and may support kidney function preservation. However, the mechanisms underlying the effectiveness of Western medications and herbal remedies in alleviating inflammation and oxidative stress occurring in renal dysfunction are not completely known. This review aims to provide a comprehensive overview of CKD treatment strategies and renal function preservation and critically discusses the existing literature’s limitations whilst offering insight into the potential antioxidant effects of these interventions. This could provide a useful guide for future clinical trials and facilitate the development of effective treatment strategies for kidney functions.


Persistent Identifierhttp://hdl.handle.net/10722/348445

 

DC FieldValueLanguage
dc.contributor.authorLee, On Ying Angela-
dc.contributor.authorWong, Alex Ngai Nick-
dc.contributor.authorHo, Ching Yan-
dc.contributor.authorTse, Ka Wai-
dc.contributor.authorChan, Angela Zaneta-
dc.contributor.authorLeung, George Pak Heng-
dc.contributor.authorKwan, Yiu Wa-
dc.contributor.authorYeung, Martin Ho Yin-
dc.date.accessioned2024-10-09T00:31:33Z-
dc.date.available2024-10-09T00:31:33Z-
dc.date.issued2024-06-20-
dc.identifier.citationAntioxidants, 2024, v. 13, n. 6-
dc.identifier.urihttp://hdl.handle.net/10722/348445-
dc.description.abstract<p>Chronic kidney disease (CKD) presents a substantial global public health challenge, with high morbidity and mortality. CKD patients often experience dyslipidaemia and poor glycaemic control, further exacerbating inflammation and oxidative stress in the kidney. If left untreated, these metabolic symptoms can progress to end-stage renal disease, necessitating long-term dialysis or kidney transplantation. Alleviating inflammation responses has become the standard approach in CKD management. Medications such as statins, metformin, and GLP-1 agonists, initially developed for treating metabolic dysregulation, demonstrate promising renal therapeutic benefits. The rising popularity of herbal remedies and supplements, perceived as natural antioxidants, has spurred investigations into their potential efficacy. Notably, lactoferrin, Boerhaavia diffusa, Amauroderma rugosum, and Ganoderma lucidum are known for their anti-inflammatory and antioxidant properties and may support kidney function preservation. However, the mechanisms underlying the effectiveness of Western medications and herbal remedies in alleviating inflammation and oxidative stress occurring in renal dysfunction are not completely known. This review aims to provide a comprehensive overview of CKD treatment strategies and renal function preservation and critically discusses the existing literature’s limitations whilst offering insight into the potential antioxidant effects of these interventions. This could provide a useful guide for future clinical trials and facilitate the development of effective treatment strategies for kidney functions.</p>-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofAntioxidants-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectantioxidants-
dc.subjectchronic kidney disease-
dc.subjectinflammation-
dc.subjectoxidative stress-
dc.subjectrenal preservation-
dc.titlePotentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease-
dc.typeArticle-
dc.identifier.doi10.3390/antiox13060751-
dc.identifier.scopuseid_2-s2.0-85197898925-
dc.identifier.volume13-
dc.identifier.issue6-
dc.identifier.eissn2076-3921-
dc.identifier.issnl2076-3921-

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