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Article: Relationship between Helicobacter pylori infection, osteoporosis, and fracture
Title | Relationship between Helicobacter pylori infection, osteoporosis, and fracture |
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Authors | |
Keywords | bone eradication therapy fracture H. pylori osteoporosis |
Issue Date | 21-Jun-2024 |
Publisher | Blackwell Science |
Citation | Journal of Gastroenterology and Hepatology, 2024, v. 39, n. 10, p. 2006-2017 How to Cite? |
Abstract | Osteoporotic fracture is a prevalent noncommunicable disease globally, causing significant mortality, morbidity, and disability. As the population ages, the healthcare and economic burden of osteoporotic fracture is expected to increase further. Due to its multifactorial features, the development of osteoporotic fracture involves a complex interplay of multiple risk factors, including genetic, environmental, and lifestyle factors. Helicobacter pylori, which infects approximately 43% of the world's population, has been associated with increased fracture risk due to hypochlorhydria from atrophic gastritis and systemic inflammation from elevated pro-inflammatory cytokines. However, the potential impact of H. pylori infection and eradication on fracture risk remains contentious among various studies due to the study design and inadequate adjustment of confounding factors including baseline gastritis phenotype. In this review, we provided a comprehensive evaluation of the current evidence focusing on the underlying mechanisms and clinical evidence of the association between H. pylori infection and osteoporotic fracture. We also discussed the potential benefits of H. pylori eradication on fracture risk. |
Persistent Identifier | http://hdl.handle.net/10722/348671 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.179 |
DC Field | Value | Language |
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dc.contributor.author | Tan, Jing Tong | - |
dc.contributor.author | Cheung, Ching Lung | - |
dc.contributor.author | Cheung, Ka Shing | - |
dc.date.accessioned | 2024-10-11T00:31:23Z | - |
dc.date.available | 2024-10-11T00:31:23Z | - |
dc.date.issued | 2024-06-21 | - |
dc.identifier.citation | Journal of Gastroenterology and Hepatology, 2024, v. 39, n. 10, p. 2006-2017 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | http://hdl.handle.net/10722/348671 | - |
dc.description.abstract | Osteoporotic fracture is a prevalent noncommunicable disease globally, causing significant mortality, morbidity, and disability. As the population ages, the healthcare and economic burden of osteoporotic fracture is expected to increase further. Due to its multifactorial features, the development of osteoporotic fracture involves a complex interplay of multiple risk factors, including genetic, environmental, and lifestyle factors. Helicobacter pylori, which infects approximately 43% of the world's population, has been associated with increased fracture risk due to hypochlorhydria from atrophic gastritis and systemic inflammation from elevated pro-inflammatory cytokines. However, the potential impact of H. pylori infection and eradication on fracture risk remains contentious among various studies due to the study design and inadequate adjustment of confounding factors including baseline gastritis phenotype. In this review, we provided a comprehensive evaluation of the current evidence focusing on the underlying mechanisms and clinical evidence of the association between H. pylori infection and osteoporotic fracture. We also discussed the potential benefits of H. pylori eradication on fracture risk. | - |
dc.language | eng | - |
dc.publisher | Blackwell Science | - |
dc.relation.ispartof | Journal of Gastroenterology and Hepatology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | bone | - |
dc.subject | eradication therapy | - |
dc.subject | fracture | - |
dc.subject | H. pylori | - |
dc.subject | osteoporosis | - |
dc.title | Relationship between Helicobacter pylori infection, osteoporosis, and fracture | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/jgh.16664 | - |
dc.identifier.scopus | eid_2-s2.0-85196638266 | - |
dc.identifier.volume | 39 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 2006 | - |
dc.identifier.epage | 2017 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.identifier.issnl | 0815-9319 | - |