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- Publisher Website: 10.2217/nnm-2016-0388
- Scopus: eid_2-s2.0-85016410326
- PMID: 28322108
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Article: Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy
Title | Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy |
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Authors | |
Keywords | glabrescione B (GlaB) Hedgehog (Hh) pathway oil-cored polymeric nanocapsules |
Issue Date | 2017 |
Citation | Nanomedicine, 2017, v. 12, n. 7, p. 711-728 How to Cite? |
Abstract | Aim: With the purpose of delivering high doses of glabrescione B (GlaB) to solid tumors after systemic administration, long-circulating GlaB-loaded oil-cored polymeric nanocapsules (NC-GlaB) were formulated. Materials & methods: Synthesis of GlaB and its encapsulation in nanocapsules (NCs) was performed. Empty and GlaB-loaded NCs were assessed for their physico-chemical properties, in vitro cytotoxicity and in vivo biodistribution. Results: GlaB was efficiently loaded into NCs (90%), which were small (160 nm), homogeneous and stable upon storage. Further, GlaB and NC-GlaB demonstrated specific activities against the cancer stem cells. Preliminary studies in tumor-bearing mice supported the ability of NC to accumulate in pancreatic tumors. Conclusion: This study provides early evidence that NC-GlaB has the potential to be utilized in a preclinical setting and justifies the need to perform therapeutic experiments in mice. |
Persistent Identifier | http://hdl.handle.net/10722/348890 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 0.670 |
DC Field | Value | Language |
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dc.contributor.author | Ingallina, Cinzia | - |
dc.contributor.author | Costa, Pedro M. | - |
dc.contributor.author | Ghirga, Francesca | - |
dc.contributor.author | Klippstein, Rebecca | - |
dc.contributor.author | Wang, Julie T. | - |
dc.contributor.author | Berardozzi, Simone | - |
dc.contributor.author | Hodgins, Naomi | - |
dc.contributor.author | Infante, Paola | - |
dc.contributor.author | Pollard, Steven M. | - |
dc.contributor.author | Botta, Bruno | - |
dc.contributor.author | Al-Jamal, Khuloud T. | - |
dc.date.accessioned | 2024-10-17T06:54:45Z | - |
dc.date.available | 2024-10-17T06:54:45Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Nanomedicine, 2017, v. 12, n. 7, p. 711-728 | - |
dc.identifier.issn | 1743-5889 | - |
dc.identifier.uri | http://hdl.handle.net/10722/348890 | - |
dc.description.abstract | Aim: With the purpose of delivering high doses of glabrescione B (GlaB) to solid tumors after systemic administration, long-circulating GlaB-loaded oil-cored polymeric nanocapsules (NC-GlaB) were formulated. Materials & methods: Synthesis of GlaB and its encapsulation in nanocapsules (NCs) was performed. Empty and GlaB-loaded NCs were assessed for their physico-chemical properties, in vitro cytotoxicity and in vivo biodistribution. Results: GlaB was efficiently loaded into NCs (90%), which were small (160 nm), homogeneous and stable upon storage. Further, GlaB and NC-GlaB demonstrated specific activities against the cancer stem cells. Preliminary studies in tumor-bearing mice supported the ability of NC to accumulate in pancreatic tumors. Conclusion: This study provides early evidence that NC-GlaB has the potential to be utilized in a preclinical setting and justifies the need to perform therapeutic experiments in mice. | - |
dc.language | eng | - |
dc.relation.ispartof | Nanomedicine | - |
dc.subject | glabrescione B (GlaB) | - |
dc.subject | Hedgehog (Hh) pathway | - |
dc.subject | oil-cored polymeric nanocapsules | - |
dc.title | Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.2217/nnm-2016-0388 | - |
dc.identifier.pmid | 28322108 | - |
dc.identifier.scopus | eid_2-s2.0-85016410326 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 711 | - |
dc.identifier.epage | 728 | - |
dc.identifier.eissn | 1748-6963 | - |