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- Publisher Website: 10.1002/smll.200701043
- Scopus: eid_2-s2.0-52649120918
- PMID: 18711753
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Article: Functionalized-quantum-dot-liposome hybrids as multimodal nanopartides for cancer
Title | Functionalized-quantum-dot-liposome hybrids as multimodal nanopartides for cancer |
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Authors | |
Keywords | Liposomes Quantum dots Spheroid penetration Theranostics Tumor imaging |
Issue Date | 2008 |
Citation | Small, 2008, v. 4, n. 9, p. 1406-1415 How to Cite? |
Abstract | Functionalized-quantum-dot-liposome (f-QD-L) hybrid nanopartides are engineered by encapsulating poly(ethylene glycol)-coated QD in the internal aqueous phase of different lipid bilayer vesicles. f-QD-L maintain the QD fluorescence characteristics as confirmed by fluorescence spectroscopy, agarose gel electrophoresis, and confocal laser scanning microscopy. Cationic f-QD-L hybrids lead to dramatic improvements in cellular binding and internalization in tumor-cell monolayer cultures. Deeper penetration into three-dimensional multicellular spheroids is obtained for f-QD-L by modifying the lipid bilayer characteristics of the hybrid system. f-QD-L are injected intratumorally into solid tumor models leading to extensive fluorescent staining of tumor cells compared to injections of the f-QD alone. f-QD-L hybrid nanopartides constitute a versatile tool for very efficient labeling of cells ex vivo and in vivo, particularly when long-term imaging and tracking of cells is sought. Moreover, f-QD-L offer many opportunities for the development of combinatory therapeutic and imaging (theranostic) modalities by incorporating both drug molecules and QD within the different compartments of a single vesicle. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA. |
Persistent Identifier | http://hdl.handle.net/10722/348910 |
ISSN | 2023 Impact Factor: 13.0 2023 SCImago Journal Rankings: 3.348 |
DC Field | Value | Language |
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dc.contributor.author | Al-Jamal, Wafa T. | - |
dc.contributor.author | Al-Jamal, Khuloud T. | - |
dc.contributor.author | Bomans, Paul H. | - |
dc.contributor.author | Frederik, Peter M. | - |
dc.contributor.author | Kostarelos, Kostas | - |
dc.date.accessioned | 2024-10-17T06:54:52Z | - |
dc.date.available | 2024-10-17T06:54:52Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Small, 2008, v. 4, n. 9, p. 1406-1415 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10722/348910 | - |
dc.description.abstract | Functionalized-quantum-dot-liposome (f-QD-L) hybrid nanopartides are engineered by encapsulating poly(ethylene glycol)-coated QD in the internal aqueous phase of different lipid bilayer vesicles. f-QD-L maintain the QD fluorescence characteristics as confirmed by fluorescence spectroscopy, agarose gel electrophoresis, and confocal laser scanning microscopy. Cationic f-QD-L hybrids lead to dramatic improvements in cellular binding and internalization in tumor-cell monolayer cultures. Deeper penetration into three-dimensional multicellular spheroids is obtained for f-QD-L by modifying the lipid bilayer characteristics of the hybrid system. f-QD-L are injected intratumorally into solid tumor models leading to extensive fluorescent staining of tumor cells compared to injections of the f-QD alone. f-QD-L hybrid nanopartides constitute a versatile tool for very efficient labeling of cells ex vivo and in vivo, particularly when long-term imaging and tracking of cells is sought. Moreover, f-QD-L offer many opportunities for the development of combinatory therapeutic and imaging (theranostic) modalities by incorporating both drug molecules and QD within the different compartments of a single vesicle. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA. | - |
dc.language | eng | - |
dc.relation.ispartof | Small | - |
dc.subject | Liposomes | - |
dc.subject | Quantum dots | - |
dc.subject | Spheroid penetration | - |
dc.subject | Theranostics | - |
dc.subject | Tumor imaging | - |
dc.title | Functionalized-quantum-dot-liposome hybrids as multimodal nanopartides for cancer | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/smll.200701043 | - |
dc.identifier.pmid | 18711753 | - |
dc.identifier.scopus | eid_2-s2.0-52649120918 | - |
dc.identifier.volume | 4 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1406 | - |
dc.identifier.epage | 1415 | - |
dc.identifier.eissn | 1613-6829 | - |