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Conference Paper: Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics

TitleMulti-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics
Authors
Ali-Boucetta, H.Al-Jamal, K. T.Kostarelos, K.
KeywordsCancer
Carbon nanotubes
Doxorubicin
Supramolecular complexes
Issue Date2008
Citation
Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, 2008, v. 2, p. 16-18 How to Cite?
AbstractThe potential of carbon nanotubes as carriers and delivery vectors for anticancer drugs was investigated. Herein, we propose MWNT-doxorubicin supramolecular complexes that can be developed for cancer therapy. The formation of such complexes is evidenced by a sharp decrease in the intensity of the doxorubicin fluorescence spectrum and takes place via π-π interactions with the MWNT backbone. In addition, the structural characteristics of the CNT-doxorubicin complexes were examined by transmission electron microscopy and showed well dispersed pluronic wrapped MWNT but clustered MWNT-doxorubicin structures. Very interestingly the doxorubicinMWNT complexes exhibit enhanced cytotoxic activity compared to both doxorubicin alone and doxorubicin-pluronic complexes.
Persistent Identifierhttp://hdl.handle.net/10722/348911

 

DC FieldValueLanguage
dc.contributor.authorAli-Boucetta, H.-
dc.contributor.authorAl-Jamal, K. T.-
dc.contributor.authorKostarelos, K.-
dc.date.accessioned2024-10-17T06:54:53Z-
dc.date.available2024-10-17T06:54:53Z-
dc.date.issued2008-
dc.identifier.citationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, 2008, v. 2, p. 16-18-
dc.identifier.urihttp://hdl.handle.net/10722/348911-
dc.description.abstractThe potential of carbon nanotubes as carriers and delivery vectors for anticancer drugs was investigated. Herein, we propose MWNT-doxorubicin supramolecular complexes that can be developed for cancer therapy. The formation of such complexes is evidenced by a sharp decrease in the intensity of the doxorubicin fluorescence spectrum and takes place via π-π interactions with the MWNT backbone. In addition, the structural characteristics of the CNT-doxorubicin complexes were examined by transmission electron microscopy and showed well dispersed pluronic wrapped MWNT but clustered MWNT-doxorubicin structures. Very interestingly the doxorubicinMWNT complexes exhibit enhanced cytotoxic activity compared to both doxorubicin alone and doxorubicin-pluronic complexes.-
dc.languageeng-
dc.relation.ispartofTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008-
dc.subjectCancer-
dc.subjectCarbon nanotubes-
dc.subjectDoxorubicin-
dc.subjectSupramolecular complexes-
dc.titleMulti-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics-
dc.typeConference_Paper-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-52649167825-
dc.identifier.volume2-
dc.identifier.spage16-
dc.identifier.epage18-

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