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- Publisher Website: 10.1016/j.proeng.2011.12.242
- Scopus: eid_2-s2.0-84863162076
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Conference Paper: An electric-field responsive microsystem for controllable miniaturised drug delivery applications
| Title | An electric-field responsive microsystem for controllable miniaturised drug delivery applications |
|---|---|
| Authors | |
| Keywords | Drug delivery Electric-field responsive Electro-active hydrogel Point of care |
| Issue Date | 2011 |
| Citation | Procedia Engineering, 2011, v. 25, p. 984-987 How to Cite? |
| Abstract | A novel MEMS based drug delivery device has been developed, consisting of an array of metallic contacts. The meander structured device created a uniform electric field which stimulates drug releases. An electro-active hydrogel based polymer matrix responds to an electrical stimulus and shrinks or de-swells on application of an electric field from the fabricated device. Different drug candidates can be encapsulated within the polymer matrix. The de-swelling of the polymer enables the encapsulated drug to be released from the matrix. The gel is able to recover its original size once electric stimulation has been stopped. By controlling the voltage and time, the drug release rate and dose can be precisely controlled. Controlled drug delivery devices may be integrated with sensor technology in combined diagnostic / therapeutic point of care devices. © 2011 Published by Elsevier Ltd. |
| Persistent Identifier | http://hdl.handle.net/10722/348972 |
| ISSN | 2020 SCImago Journal Rankings: 0.320 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Liu, Y. | - |
| dc.contributor.author | Servant, A. | - |
| dc.contributor.author | Guy, O. J. | - |
| dc.contributor.author | Al-Jamal, K. T. | - |
| dc.contributor.author | Williams, P. R. | - |
| dc.contributor.author | Hawkins, K. M. | - |
| dc.contributor.author | Kostarelos, K. | - |
| dc.date.accessioned | 2024-10-17T06:55:18Z | - |
| dc.date.available | 2024-10-17T06:55:18Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier.citation | Procedia Engineering, 2011, v. 25, p. 984-987 | - |
| dc.identifier.issn | 1877-7058 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/348972 | - |
| dc.description.abstract | A novel MEMS based drug delivery device has been developed, consisting of an array of metallic contacts. The meander structured device created a uniform electric field which stimulates drug releases. An electro-active hydrogel based polymer matrix responds to an electrical stimulus and shrinks or de-swells on application of an electric field from the fabricated device. Different drug candidates can be encapsulated within the polymer matrix. The de-swelling of the polymer enables the encapsulated drug to be released from the matrix. The gel is able to recover its original size once electric stimulation has been stopped. By controlling the voltage and time, the drug release rate and dose can be precisely controlled. Controlled drug delivery devices may be integrated with sensor technology in combined diagnostic / therapeutic point of care devices. © 2011 Published by Elsevier Ltd. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Procedia Engineering | - |
| dc.subject | Drug delivery | - |
| dc.subject | Electric-field responsive | - |
| dc.subject | Electro-active hydrogel | - |
| dc.subject | Point of care | - |
| dc.title | An electric-field responsive microsystem for controllable miniaturised drug delivery applications | - |
| dc.type | Conference_Paper | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1016/j.proeng.2011.12.242 | - |
| dc.identifier.scopus | eid_2-s2.0-84863162076 | - |
| dc.identifier.volume | 25 | - |
| dc.identifier.spage | 984 | - |
| dc.identifier.epage | 987 | - |