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- Publisher Website: 10.2217/nnm-2018-0289
- Scopus: eid_2-s2.0-85063813926
- PMID: 30874464
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Article: Asenapine maleate-loaded nanostructured lipid carriers: Optimization and in vitro, ex vivo and in vivo evaluations
Title | Asenapine maleate-loaded nanostructured lipid carriers: Optimization and in vitro, ex vivo and in vivo evaluations |
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Authors | |
Keywords | asenapine maleate Caco 2 cells in vivo imaging nanostructured lipid carriers |
Issue Date | 2019 |
Citation | Nanomedicine, 2019, v. 14, n. 7, p. 889-910 How to Cite? |
Abstract | Aim: To prepare nanostructured lipid carriers (NLCs) loaded with asenapine maleate (ASPM) to increase its oral bioavailability by intestinal lymphatic uptake. Materials & methods: ASPM-NLCs were prepared by ultrasound dispersion technique, by adopting Design of Experiment approach, and characterized. Results: The optimized formulation exhibited good physicochemical parameters. Differential scanning calorimetry and x-ray diffraction studies indicated the amorphized nature of ASPM in lipid matrix. In vitro drug release study indicated the sustained release of drug from NLCs. ASPM-NLCs showed greater permeability across Caco2 cells and everted rat ileum. ASPM-NLCs showed greater cellular uptake, superior preclinical oral bioavailability and higher efficacy in reducing the L-DOPA-carbidopa-induced locomotor count compared with plain drug. Conclusion: ASPM-NLCs were successfully developed that showed enhanced performance both in vitro and in vivo. |
Persistent Identifier | http://hdl.handle.net/10722/349322 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 0.670 |
DC Field | Value | Language |
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dc.contributor.author | Managuli, Renuka S. | - |
dc.contributor.author | Wang, Julie T. | - |
dc.contributor.author | Faruqu, Farid N. | - |
dc.contributor.author | Kushwah, Varun | - |
dc.contributor.author | Raut, Sushil Y. | - |
dc.contributor.author | Shreya, Ajjappla B. | - |
dc.contributor.author | Al-Jamal, Khuloud T. | - |
dc.contributor.author | Jain, Sanyog | - |
dc.contributor.author | Mutalik, Srinivas | - |
dc.date.accessioned | 2024-10-17T06:57:46Z | - |
dc.date.available | 2024-10-17T06:57:46Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Nanomedicine, 2019, v. 14, n. 7, p. 889-910 | - |
dc.identifier.issn | 1743-5889 | - |
dc.identifier.uri | http://hdl.handle.net/10722/349322 | - |
dc.description.abstract | Aim: To prepare nanostructured lipid carriers (NLCs) loaded with asenapine maleate (ASPM) to increase its oral bioavailability by intestinal lymphatic uptake. Materials & methods: ASPM-NLCs were prepared by ultrasound dispersion technique, by adopting Design of Experiment approach, and characterized. Results: The optimized formulation exhibited good physicochemical parameters. Differential scanning calorimetry and x-ray diffraction studies indicated the amorphized nature of ASPM in lipid matrix. In vitro drug release study indicated the sustained release of drug from NLCs. ASPM-NLCs showed greater permeability across Caco2 cells and everted rat ileum. ASPM-NLCs showed greater cellular uptake, superior preclinical oral bioavailability and higher efficacy in reducing the L-DOPA-carbidopa-induced locomotor count compared with plain drug. Conclusion: ASPM-NLCs were successfully developed that showed enhanced performance both in vitro and in vivo. | - |
dc.language | eng | - |
dc.relation.ispartof | Nanomedicine | - |
dc.subject | asenapine maleate | - |
dc.subject | Caco 2 cells | - |
dc.subject | in vivo imaging | - |
dc.subject | nanostructured lipid carriers | - |
dc.title | Asenapine maleate-loaded nanostructured lipid carriers: Optimization and in vitro, ex vivo and in vivo evaluations | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.2217/nnm-2018-0289 | - |
dc.identifier.pmid | 30874464 | - |
dc.identifier.scopus | eid_2-s2.0-85063813926 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 889 | - |
dc.identifier.epage | 910 | - |
dc.identifier.eissn | 1748-6963 | - |